TNFRSF1A / TNFR1 Polyclonal Antibody (NHP-AB479)

• This product is an antibody that was generated by immunizing rabbit against synthetic peptide derived from the sequence of mouse TNF-R11. It is used only in in vitro assays.

Detailed Product Description

• Introduction: TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.
• Conjugate: None
• Applications: IHC; IP; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bovine; Dog; Drosophila; Hamster; Human; Monkey; Mouse; Pig; Rabbit; Rat; Sheep; Xenopus; Yeast
• Immunogen: Synthetic peptide derived from the sequence of mouse TNF-R11

Product Property

• Purification: Affinity Purified
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.09% azide, 50% glycerol
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: CD120a; CD120a antigen; MGC19588; n-smase activation assoc. factor; p55; p60; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TBPI; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A, membrane form; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; Tumor necrosis factor-binding protein 1
• Entrez Gene ID: 7132