Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs now offers high-quality membrane protein production service utilizing L. lactis system. Empowered by advanced technology platforms and extensive experience in this field, we are dedicated to tailoring various reliable and functional membrane protein products to our worldwide customers.
Since the natural abundance of most membrane proteins is quite low, recombinant expression in heterologous systems is a common option to prepare membrane proteins for functional studies, structure determination, antibody development, etc. Among all kinds of recombinant expression systems (e.g. E. coli., insect, yeast), L. lactis (Lactococcus lactis) has emerged as a useful Gram-positive bacterial system for functional expression of membrane proteins in recent years. Compared with the most widely used Gram-negative Escherichia coli expression system, L. lactis, which is tightly regulated by nisin-controlled gene expression (NICE) system, has more attractive features for eukaryotic membrane protein targets. This well-characterized system is highly versatile and has been widely used in pharmaceutical, medical, and bio- and food-technology applications.
Fig 1 Nisin-controlled gene expression (NICE) system in L. lactis.
Scientists in Creative Biolabs has rich experience in generating membrane proteins in L. lactis system, including GPCRs, ion channels, and transporters. We offer featured one-stop custom service from initial vector design and construction, protein expression, purification and reconstitution from small to large scales. Besides, versatile reconstitution formats such as liposomes, nanodiscs, polymers, etc. can be utilized to stabilize membrane proteins in proper states. Our technical team will be working closely with you step by step to guarantee the most satisfactory outcomes.
Advantages of L. lactis as the host organism for membrane protein expression include:
With more than a decade’s experience, Creative Biolabs has long been devoted to offering time- and cost-saving membrane protein services to address diverse custom demands. Based on our all-around Magic™ membrane protein platform, we are able to offer customized solutions to satisfy each specific requirement. As alternatives, we also provide featured membrane protein preparation services using following cellular mechanisms:
Moreover, we also perform various functional validation assay to monitor the quality of membrane proteins. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
