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Anti-MIgG(Fc)-C-PBD ADC (ADC-AA-058)

This ADC product is comprised of an anti-mouse IgG Fc specific polyclonal antibody conjugated via a cleavable linker to PBD (pyrrolobenzodiazepine). The antibody portion is a polyclonal antibody and the drug portion, PBD, is a cytotoxic small molecule which binds to DNA minor groove and cross-links specific sites of DNA. The cleavable linker connecting PBD to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis.

 ADC Target

  • Overview
  • The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.

 ADC Antibody

  • Overview
  • Anti-mouse IgG Fc specific polyclonal IgG antibody
  • Species Reactivity
  • Mouse

 ADC Linker

  • Name
  • Cleavable linkers
  • Description
  • Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.

 ADC payload drug

  • Name
  • PBD (pyrrolobenzodiazepine)
  • Description
  • Derived from various actinomycetes that show strong anti-tumor or antibiotic activities. PBDs are sequence-dependent DNA alkylating compounds and are proven to be more powerful than systemic chemotherapeutic drugs. As DNA minor groove binding agents, PBDs selectively cross-link specific DNA segments, hindering cell division and eventually lead to cell death.

For Research Use Only. NOT FOR CLINICAL USE.

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