IgG Fc

Immunoglobulin G (IgG) is the most abundant type of antibody found in blood and extracellular fluid and protects body from various bacterial and viral infections by binding those pathogens. IgG antibody is a 150 kDa tetrameric quaternary structure which contains two identical class γ heavy chains of about 50 kDa and two identical light chains of about 25 kDa. The two heavy chains are linked to each other and to a light chain each by disulfide bonds, resulting in a Y-like shape. The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG contains a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-AA-001  anti-HIgG(Fc)-N-MMAF ADC anti-human IgG Fc specific polyclonal IgG antibody Noncleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-002  anti-HIgG(Fc)-C-MMAF ADC anti-human IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-003  anti-HIgG(Fc)-C-MMAE ADC anti-human IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-004 anti-HIgG(Fc)-C-MD10 ADC anti-human IgG Fc specific polyclonal IgG antibody Cleavable linkers MD10 (monomethyl dolastatin 10 ) Inquiry
ADC-AA-005 anti-HIgG(Fc)-C-DMSA ADC anti-human IgG Fc specific polyclonal IgG antibody Cleavable linkers DMSA (duocarmycin SA) Inquiry
ADC-AA-006 anti-HIgG(Fc)-C-DMDM ADC anti-human IgG Fc specific polyclonal IgG antibody Cleavable linkers DMDM (duocarmycin DM) Inquiry
ADC-AA-007 anti-HIgG(Fc)-C-PNU ADC anti-human IgG Fc specific polyclonal IgG antibody Cleavable linkers PNU-159682 Inquiry
ADC-AA-008  anti-HIgG(Fc)-N-DM1 ADC anti-human IgG Fc specific polyclonal IgG antibody Noncleavable linkers DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-AA-057  Anti-MIgG (clone HB43)-VC-MMAE ADC Anti-mouse IgG Antibody, clone # HB43 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-056  Anti-MIgG (clone 187.1)-VC-MMAE ADC Anti-mouse IgG Antibody, clone # q187.1 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-019  anti-MIgG(Fc)-N-MMAF ADC anti-mouse IgG Fc specific polyclonal IgG antibody Noncleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-020  anti-MIgG(Fc)-C-MMAF ADC anti-mouse IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-021  anti-MIgG(Fc)-C-MMAE ADC anti-mouse IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-022 anti-MIgG(Fc)-C-MD10 ADC anti-mouse IgG Fc specific polyclonal IgG antibody Cleavable linkers MD10 (monomethyl dolastatin 10 ) Inquiry
ADC-AA-023 anti-MIgG(Fc)-C-DMSA ADC anti-mouse IgG Fc specific polyclonal IgG antibody Cleavable linkers DMSA (duocarmycin SA) Inquiry
ADC-AA-024 anti-MIgG(Fc)-C-DMDM ADC anti-mouse IgG Fc specific polyclonal IgG antibody Cleavable linkers DMDM (duocarmycin DM) Inquiry
ADC-AA-025 anti-MIgG(Fc)-C-PNU ADC anti-mouse IgG Fc specific polyclonal IgG antibody Cleavable linkers PNU-159682 Inquiry
ADC-AA-026  anti-MIgG(Fc)-N-DM1 ADC anti-mouse IgG Fc specific polyclonal IgG antibody Noncleavable linkers DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-AA-032 anti-RIgG(Fc)-N-MMAF ADC anti-rabbit IgG Fc specific polyclonal IgG antibody Noncleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-039 anti-Rat IgG(Fc)-N-MMAF ADC anti-rat IgG Fc specific polyclonal IgG antibody Noncleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-040 anti-Rat IgG(Fc)-C-MMAF ADC anti-rat IgG Fc specific polyclonal IgG antibody Cleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-033 anti-RIgG(Fc)Fab-N-MMAF ADC Fab fragment of anti-rabbit IgG Fc specific polyclonal antibody Noncleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-041 anti-Rat IgG(Fc)Fab-N-MMAF ADC Fab fragment of anti-rat IgG Fc specific polyclonal antibody Noncleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-042 anti-Rat IgG(Fc)Fab-C-MMAF ADC Fab fragment of anti-rat IgG Fc specific polyclonal antibody Cleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-043 anti-Rat IgG(Fc)Fab-C-MMAE ADC Fab fragment of anti-rat IgG Fc specific polyclonal antibody Cleavable linkers MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-044 anti-Rat IgG(Fc)Fab-C-DMDM ADC Fab fragment of anti-rat IgG Fc specific polyclonal antibody Cleavable linkers DMDM (duocarmycin DM) Inquiry
ADC-AA-009  anti-HIgG(Fc)Fab-N-MMAF ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Noncleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-010  anti-HIgG(Fc)Fab-C-MMAF ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Cleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-011  anti-HIgG(Fc)Fab-C-MMAE ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Cleavable linkers MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-012 anti-HIgG(Fc)Fab-C-DMSA ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Cleavable linkers DMSA (duocarmycin SA) Inquiry
ADC-AA-013 anti-HIgG(Fc)Fab-C-DMDM ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Cleavable linkers DMDM (duocarmycin DM) Inquiry
ADC-AA-014 anti-HIgG(Fc)Fab-C-PNU ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Cleavable linkers PNU-159682 Inquiry
ADC-AA-015  anti-HIgG(Fc)Fab-N-DM1 ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Noncleavable linkers DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-AA-016 anti-HIgG(Fc)Fab-N-AAMT ADC Fab fragment of anti-human IgG Fc specific polyclonal antibody Noncleavable linkers Alfa-amanitin Inquiry
ADC-AA-027  anti-MIgG(Fc)Fab-N-MMAF ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Noncleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-028  anti-MIgG(Fc)Fab-C-MMAF ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Cleavable linkers MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-029  anti-MIgG(Fc)Fab-C-MMAE ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Cleavable linkers MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-030 anti-MIgG(Fc)Fab-C-DMDM ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Cleavable linkers DMDM (duocarmycin DM) Inquiry
ADC-AA-031  anti-MIgG(Fc)Fab-N-DM1 ADC Fab fragment of anti-mouse IgG Fc specific polyclonal antibody Noncleavable linkers DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-AA-052  Protein A-VC-MMAE ADC Protein A VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-053  Protein A-MMAF ADC Protein A MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-054  Protein A-MCC-DM1 ADC Protein A MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-AA-055  Protein A-Duocarmycin ADC Protein A Duocarmycins Inquiry
ADC-AA-048  Protein G-VC-MMAE ADC Protein G VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-AA-049  Protein G-MMAF ADC Protein G MMAF (Monomethyl auristatin F) Inquiry
ADC-AA-050  Protein G-MCC-DM1 ADC Protein G MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-AA-051  Protein G-Duocarmycin ADC Protein G Duocarmycins Inquiry
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 45-1 Ramsey Road, Shirley, NY 11967, USA
 Tel: 1-631-381-2994
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