Complement C3d receptor 2 (CR2), also known as CD21, CVID7, SLEB9, CR C3DR, complement receptor type 2 or Epstein-Barr virus (EBV) receptor, is a 145 kDa transmembrane protein that belongs the receptors of complement activation (RCA) family. Mature human CD21 is 1013 amino acids (aa) in length, containing a 951-aa extracellular domain (ECD) and a short 34-aa cytoplasmic tail. It is reported that the ECD of human CD21 shares 71% amino acids identity with mouse CD21 ECD.

CR2 is expressed on mature B and T lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen. When expressed on mature B cells, CR2 can form a complex with CD19 and CD81, so-called the B cell co-receptor complex, which enhances B cell response to the antigen. In addition, this protein is involved in Epstein-Barr virus (EBV) infections and it functions as a receptor for this virus binding on B cells and T cells.

Gene ID: 1380
UniProt ID: P20023

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-330 Anti-CR2 (clone HB135)-MCC-DM1 ADC Anti-CR2 antibody, clone # HB135 MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-621 Anti-CR2 (THB-5)-SPP-DM1 ADC Anti-CR2 IgG2a Antibody, THB-5 SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-622 Anti-CR2 (THB-5)-MCC-DM1 ADC Anti-CR2 IgG2a Antibody, THB-5 MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-623 Anti-CR2 (THB-5)-Mc-VC-PABC-MMAE ADC Anti-CR2 IgG2a Antibody, THB-5 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-624 Anti-CR2 (THB-5)-Mc-MMAF ADC Anti-CR2 IgG2a Antibody, THB-5 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
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