Anti-drug Abs

Antibody-drug conjugates (ADCs) are new-generation anti-cancer immunotherapeutic agents that accurately deliver cytotoxic agents to cancer cells to achieve caner elimination without damaging normal tissues. ADCs carry extremely high potent toxins and their pharmacokinetic properties and safety profile need to be extensively evaluated before deploying to human clinical trials. One crucial aspect in ADC pharmacokinetic (PK) property is the ratio of total and conjugated antibody after certain time period of deployment. This is usually assayed using immuno-colorimetric assay methods such as ELISA. To detect and quantify conjugated antibody, an agent that targets the drug portion of the ADC is desired.

Due to the high potency of ADC toxins, antibodies against these chemical compounds are difficult to develop. Only low dosages of a toxin can be applied for animal immunization and the corresponding immune response is low in small rodents. After devoting a tremendous amount of effort, Creative Biolabs has raised a series of antibodies, collectively anti-drug Abs, against ADC toxin antigens include MMAE, MMAF, DM1, DM4, Calicheamicin, Duocarmycin…. These anti-drug Abs will be valuable assets to facilitate the PK and safety evaluation of newly developed ADCs bearing these drugs.

Anti-drug Abs

List of the anti-drug Ab products

Product overview: This product is a rabbit polyclonal antibody which specifically againsts the linker-payload vc-PAB-MMAE. MMAE is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin. This product is for research purposes only, not for use in diagnostics.
Host animal: rabbit
Payload Category: Tubulin inhibitor
Product overview: This product is a mouse monoclonal antibody which specifically againsts the linker-payload vc-PAB-MMAE. MMAE is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: Tubulin inhibitor
Product overview: This product is a rabbit polyclonal antibody which specifically againsts the payload MMAF. MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin. This product is for research purposes only, not for use in diagnostics.
Host animal: rabbit
Payload Category: Tubulin inhibitor
Product overview: This product is a mouse monoclonal antibody which specifically againsts the payload MMAF. MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: Tubulin inhibitor
Product overview: This product is a mouse monoclonal antibody (clone m1) which specifically againsts the payload MMAE or MMAF. MMAE and MMAF are antitubulin agent that inhibit cell division by blocking the polymerization of tubulin. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: Tubulin inhibitor
Product overview: This product is a mouse monoclonal antibody (clone m2) which specifically againsts the payload MMAE or MMAF. MMAE and MMAF are antitubulin agent that inhibit cell division by blocking the polymerization of tubulin. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: Tubulin inhibitor
Product overview: This product is a rabbit polyclonal antibody which specifically againsts the payload DM1 or DM4. DM1 and DM4 can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells. This product is for research purposes only, not for use in diagnostics.
Host animal: rabbit
Payload Category: Tubulin inhibitor
Product overview: This product is a mouse monoclonal antibody (clone d1) which specifically againsts the payload DM1 or DM4. DM1 and DM4 can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: Tubulin inhibitor
Product overview: This product is a mouse monoclonal antibody (clone d2) which specifically againsts the payload DM1 or DM4. DM1 and DM4 can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: Tubulin inhibitor
Product overview: This product is a rabbit polyclonal antibody which specifically againsts the payload Calicheamicin. Calicheamicin targets DNA and cause strand scission. This product is for research purposes only, not for use in diagnostics.
Host animal: rabbit
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone c1) which specifically againsts the payload Calicheamicin. Calicheamicin targets DNA and cause strand scission. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone c2) which specifically againsts the payload Calicheamicin. Calicheamicin targets DNA and cause strand scission. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a rabbit polyclonal antibody which specifically againsts the payload duocarmycin. Duocarmycin binds to the minor groove of DNA and alkylate the nucleobase adenine at the N3 position, which eventually leads to cell death. This product is for research purposes only, not for use in diagnostics.
Host animal: rabbit
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone du1) which specifically againsts the payload duocarmycin. Duocarmycin binds to the minor groove of DNA and alkylate the nucleobase adenine at the N3 position, which eventually leads to cell death. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone du2) which specifically againsts the payload duocarmycin. Duocarmycin binds to the minor groove of DNA and alkylate the nucleobase adenine at the N3 position, which eventually leads to cell death. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone du3) which specifically againsts the payload duocarmycin. Duocarmycin binds to the minor groove of DNA and alkylate the nucleobase adenine at the N3 position, which eventually leads to cell death. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a rabbit polyclonal antibody which specifically againsts the payload PUN-159682. PUN-159682 is a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, and it is a topoisomerase inhibitor. This product is for research purposes only, not for use in diagnostics.
Host animal: rabbit
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone p1) which specifically againsts the payload PUN-159682. PUN-159682 is a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, and it is a topoisomerase inhibitor. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone p2) which specifically againsts the payload PUN-159682. PUN-159682 is a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, and it is a topoisomerase inhibitor. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone p3) which specifically againsts the payload PUN-159682. PUN-159682 is a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, and it is a topoisomerase inhibitor. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a rabbit polyclonal antibody which specifically againsts the payload amanitin. Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II. This product is for research purposes only, not for use in diagnostics.
Host animal: rabbit
Payload Category: RNA polymerase Ⅱ inhibitor
Product overview: This product is a mouse monoclonal antibody (clone a1) which specifically againsts the payload amanitin. Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: RNA polymerase Ⅱ inhibitor
Product overview: This product is a mouse monoclonal antibody (clone a2) which specifically againsts the payload amanitin. Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: RNA polymerase Ⅱ inhibitor
Product overview: This product is a mouse monoclonal antibody (clone a3) which specifically againsts the payload amanitin. Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: RNA polymerase Ⅱ inhibitor
Product overview: This product is a rabbit polyclonal antibody which specifically againsts the payload pyrrolobenzodiazepine (PBD). PBD are a class of sequence-selective DNA minor-groove binding crosslinking agents, which are significantly more potent than systemic chemotherapeutic drugs. This product is for research purposes only, not for use in diagnostics.
Host animal: rabbit
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone pb1) which specifically againsts the payload pyrrolobenzodiazepine (PBD). PBD are a class of sequence-selective DNA minor-groove binding crosslinking agents, which are significantly more potent than systemic chemotherapeutic drugs. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone pb2) which specifically againsts the payload pyrrolobenzodiazepine (PBD). PBD are a class of sequence-selective DNA minor-groove binding crosslinking agents, which are significantly more potent than systemic chemotherapeutic drugs. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
Product overview: This product is a mouse monoclonal antibody (clone pb3) which specifically againsts the payload pyrrolobenzodiazepine (PBD). PBD are a class of sequence-selective DNA minor-groove binding crosslinking agents, which are significantly more potent than systemic chemotherapeutic drugs. This product is for research purposes only, not for use in diagnostics.
Host animal: mouse
Payload Category: DNA inhibitor
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