FUT3

Fucosyltransferase 3 (FUT3), also known as blood group Lewis alpha -4-fucosyltransferase (Lewis FT), CD174, LE, Les, FT3B, FucT-III or galactoside 3(4)-L-fucosyltransferase, is a type II membrane protein that belongs to the fucosyltransferase family. This protein is 361 amino acid (aa) in length and it consists of a 15-aa cytoplasmic tail, a 19-aa transmembrane region and a 327-aa ectodomain. It is reported that 99% of the human FUT3 amino acid sequence is identical to that of chimpanzee.

The protein encoded by FUT3 gene is an enzyme with both alpha (1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities, catalyzing the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. Researches have shown that Fucosyltransferase 3 may catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. In addition, this protein may play a role in blood group Lewis determination and mutations in FUT3 gene are responsible for the majority of Lewis antigen-negative phenotypes.

Gene ID: 2525
UniProt ID: P21217

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-423 Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC Anti-FUT3 lgG3 Antibody, clone # BR96 hydrazone doxorubicin Inquiry
ADC-W-463 Anti-FUT3 (clone BR 96)-Mc-Dox ADC Chimeric Anti-FUT3 Antibody, clone # BR 96 Mc (maleimidocaproyl) Doxorubicin Inquiry
ADC-W-604  Anti-FUT3 (clone BR96)-Mc-VC-PABC-MMAF ADC b-BR96-MMAF Chimeric Anti-FUT3 IgG1 Antibody, clone # BR96 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-424 Anti-FUT3 (clone cBR96)-VC-MMAE ADC Humanized Anti-FUT3 Antibody, clone # cBR96 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-459  Anti-FUT3 (clone hu3S193)-AcBut-CalichDMH ADC CMD-193 Humanized Anti-FUT3 lgG1 Antibody, hu3S193  AcBut [-(4' acetyl phenoxy) butanoic acid] CalichDMH Inquiry
If you can’t find your product on this list? Please directly send email to

Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
*Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.


Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.


Contact us
 45-1 Ramsey Road, Shirley, NY 11967, USA
 Tel: 1-631-381-2994
 Fax: 1-631-207-8356
 Email:

Inquiry

Top