Fucosyltransferase 3 (FUT3), also known as blood group Lewis alpha -4-fucosyltransferase (Lewis FT), CD174, LE, Les, FT3B, FucT-III or galactoside 3(4)-L-fucosyltransferase, is a type II membrane protein that belongs to the fucosyltransferase family. This protein is 361 amino acid (aa) in length and it consists of a 15-aa cytoplasmic tail, a 19-aa transmembrane region and a 327-aa ectodomain. It is reported that 99% of the human FUT3 amino acid sequence is identical to that of chimpanzee.

The protein encoded by FUT3 gene is an enzyme with both alpha (1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities, catalyzing the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. Researches have shown that Fucosyltransferase 3 may catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. In addition, this protein may play a role in blood group Lewis determination and mutations in FUT3 gene are responsible for the majority of Lewis antigen-negative phenotypes.

Gene ID: 2525
UniProt ID: P21217

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-459  Anti-FUT3 (clone hu3S193)-AcBut-CalichDMH ADC CMD-193 Humanized Anti-FUT3 lgG1 Antibody, hu3S193  AcBut [-(4' acetyl phenoxy) butanoic acid] CalichDMH Inquiry
ADC-W-604  Anti-FUT3 (clone BR96)-Mc-VC-PABC-MMAF ADC b-BR96-MMAF Chimeric Anti-FUT3 IgG1 Antibody, clone # BR96 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-463 Anti-FUT3 (clone BR 96)-Mc-Dox ADC Chimeric Anti-FUT3 Antibody, clone # BR 96 Mc (maleimidocaproyl) Doxorubicin Inquiry
ADC-W-423 Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC Anti-FUT3 lgG3 Antibody, clone # BR96 hydrazone doxorubicin Inquiry
ADC-W-424 Anti-FUT3 (clone cBR96)-VC-MMAE ADC Humanized Anti-FUT3 Antibody, clone # cBR96 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry