NOTCH1

The NOTCH gene was discovered by Morgan T.H. in Drosophila melanogaster nearly a century ago. The absence of NOTCH genes leads to a defective wing in Drosophila. Encoded by NOTCH1 gene, NOTCH1 is a member of the NOTCH family. Members of this family share structural characteristics. They have similar intracellular domains and extracellular domains. The intracellular domain consists of multiple, different domain types. And the extracellular domain is composed of multiple epidermal growth factor-like repeats.
NOTCH 1 is involved in an evolutionary conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of NOTCH family receptors to their cognate ligands. NOTCH1 undergoes the proteolytical process in the trans-Golgi network. Furthermore, two polypeptide chains are generated. These peptides heterodimerize to form the mature cell-surface receptor. This receptor functions in the development of a number of cells and tissue types. Activated NOTCH1 and NOTCH3 promote differentiation of progenitor cells into astroglia. When activated before birth, NOTCH1 induces radial glia differentiation.
The NOTCH1 pathway is reported to induce EMT in several diseases. NOTCH signaling influenced several cellular processes such as proliferation, differentiation and programmed cell death. NOTCH1 signaling pathway plays an essential role in the growth and differentiation in developing lens.
Entrez Gene ID: 4851
UniProt ID: P46531