PECAM-1 Monoclonal Antibody (SPM254) (NHP-AB163)

• This product is an antibody that was generated by immunizing mouse against human recombinant PECAM-1 / CD31 protein. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Platelet endothelial cell adhesion molecule-1 (PECAM-1), also known as CD 31, is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
• Conjugate: None
• Antibody Isotype: IgG1κ
• Applications: Flow Cytometry; IF; IHC; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Cynomolgus; Human; Rabbit
• Immunogen: Human recombinant PECAM-1 / CD31 protein

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C. Avoid freez-thaw cycles.

Target Information

• Target: PECAM-1
• Clone: SPM254
• Clonality: Monoclonal
• Alternative Names: CD31; PECAM-1; Platelet endothelial cell adhesion molecule
• Entrez Gene ID: 5175