Category:
Non-Human Primate (NHP) related Antibody Products
PIGR Polyclonal Antibody (NHP-AB424)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against synthetic 18 amino acid peptide from cytoplasmic domain of human PIGR. It is used only in in vitro assays.
Introduction:
Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process. SC and the pIgR are crucial for proper mucosal immunity where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids.
Conjugate:
None
Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Gibbon; Gorilla; Human; Monkey; Orangutan
Immunogen:
Synthetic 18 amino acid peptide from cytoplasmic domain of human PIGR
Purification:
Immunoaffinity Chromatography
Format:
Liquid
Concentration:
1 mg/mL
Buffer:
PBS, 0.1% sodium azide
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
Hepatocellular carcinoma associated protein TB6; Hepatocellular carcinoma-associated protein TB6; PIgR; Poly Ig receptor; poly-Ig receptor; Polymeric immunoglobulin receptor; Secretory component; tb6
Entrez Gene ID:
5284
- PIGR Polyclonal Antibody (NHP-AB424) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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