PIGR Polyclonal Antibody (NHP-AB424)

• This product is an antibody that was generated by immunizing rabbit against synthetic 18 amino acid peptide from cytoplasmic domain of human PIGR. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process. SC and the pIgR are crucial for proper mucosal immunity where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids.
• Conjugate: None
• Applications: IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Gibbon; Gorilla; Human; Monkey; Orangutan
• Immunogen: Synthetic 18 amino acid peptide from cytoplasmic domain of human PIGR

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.1% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: Hepatocellular carcinoma associated protein TB6; Hepatocellular carcinoma-associated protein TB6; PIgR; Poly Ig receptor; poly-Ig receptor; Polymeric immunoglobulin receptor; Secretory component; tb6
• Entrez Gene ID: 5284