Natural Autoantibody Application
As an important part of the immune system, natural autoantibodies (NAA) have gotten extensive attention in the immunology research. With experienced scientists and high-end technologies, Creative Biolabs has successfully developed a whole set of innovative and diversified NAA platforms to provide fast and convenient services for our worldwide customers. Now, we can provide the largest and most diverse portfolio of premade or custom NAA products or services to help you get milestone development.
NAA Introduction
Natural autoantibodies (NAA) are a kind of immunoglobulins that are spontaneously and constitutively secreted by the B1 type of lymphocytes in the absence of external antigen stimulation or immunization. Particularly belonging to IgM isotype, NAA play an important role not only in eliminating invaded pathogens but also in maintaining homeostasis of the immune system by prevention of autoimmune and inflammatory reactions. Low-serum titer, low-affinity to antigens, polyreactivity and connectivity are the main characteristics of NAA. In the early stage of some diseases, NAA are biologically amplified and hence may be measurable, making them promising biomarkers to discriminate the pathological changes from healthy tissue accurately. NAA detection and profiling present an alternative to clinical diagnosis with advantages of minimalist hardware, short time-frames, and an abundance of targets.
Fig.1 Overview of protective properties of NAbs specific to oxidation-specific epitopes (OSEs). (Tsiantoulas, 2013)
Various Applications of NAA
With the development of high throughput technologies and complementary advanced sequencing technologies, NAA are detectable in blood samples from patients or healthy individuals, which guarantees a wide range of clinical applications of NAA.
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Application in IVIg
Widely used in a broad range of autoimmune and systemic inflammatory disorders, intravenous immunoglobulin (IVIg) has become a novel and efficient method in the clinic. IVIg is a therapeutic pool containing normal polyspecific human IgG obtained from large numbers of healthy donors, thus IVIg contains the wide spectrum of NAA and ‘immune’ antibodies expressed in normal human serum. IVIg has shown good curative effect with prolonged suppression of disease-related autoantibodies in patients with autoimmune diseases treated with IVIg.
Fig.2 IVIG usage in 2011 and 2012. (Karim, 2013)
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Clinical Diagnosis
The profiling of the NAA repertoire with protein arrays might expedite the diagnosis and therapy of immune disorders, allowing not only the rapid diagnosis after the onset of the disease, but also the early detection of individuals susceptible to develop immune disorders. A large number of NAA targets have been discovered in recent years, which may be potential clinical indicators for disease diagnosis.
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NAA in Vaccine Development
The accumulation of multidisciplinary knowledge and the investment of massive funding have enabled the development of vaccines against many infectious diseases and other diseases including malignant tumors. NAA repertoire can help identify novel and effective disease targets, which may act as potential candidates for vaccine development.
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Tumor Surveillance
Cancer neoantigens can reflect tumorigenesis, but they are hardly detectable at the early stage, while NAA can bind to cell surface antigens on malignant cells, recognizing the cancerous cells, discriminating early cancer from healthy tissue, and retarding tumor development. So, NAA play an important role in immune surveillance against cancers.
Why Choose Us?
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Industry leadership
Our industry-leading expertise in the biopharma research and scalable formulation can help you promote your therapeutics and medical projects.
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Professional scientists
Our scientists are specialized in regulatory knowledge and scientific applications specific to NAA detection and profiling.
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Abundant experience
We have successfully completed a lot of NAA projects, accumulating rich experience. We can tailor processes to your program while maintaining scientific integrity and ensuring compliance with regulatory requirements.
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Superior service
Aided by our seasoned technology, our scientific team can provide the most diverse portfolio of premade or custom NAA products with best after-sale service, and one-stop pipeline NAA services with low-cost and high efficiency.
Creative Biolabs is capable to provide comprehensive products and services about NAA. Our proven and optimized platforms can help you quickly get satisfactory results without repeated trials. We also provide custom services based on the requirements of the clients to meet the specific demand. If you are interested, please contact us for more information.
References:
- Tsiantoulas, D.; et al. B-1 cell immunoglobulin directed against oxidation-specific epitopes. Frontiers in immunology. 2013, 3: 415.
- Karim, S.; et al. Are We Appropriately Using Intravenous Immunoglobulin In The Saskatoon Health Region? 2013, 4825.