NAA Associated Lung Hemorrhage Nephritis Syndrome (Goodpasture Syndrome)
Goodpasture syndrome is a rare but serious autoimmune disease that occurs when the body's immune system mistakenly produces autoantibodies against collagen in the lungs and kidneys. Recently, circulating autoantibodies directed against multiple autoantigens are found in Goodpasture syndrome. As a well-recognized leader in natural autoantibody (NAA) profiling and disease diagnosis, Creative Biolabs has committed to providing professional strategies and improved NAA services for our customers throughout the world. We have successfully developed a series of innovative and diversified NAA platforms to offer one-stop NAA services based on the Goodpasture syndrome.
Background of Goodpasture Syndrome
Goodpasture syndrome, also known as anti-glomerular basement membrane disease, is a rare and potentially life-threatening autoimmune disease. It occurs when the body's immune system mistakenly produces autoantibodies against collagen in the lungs and kidneys and these autoantibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure. Goodpasture syndrome may quickly result in permanent lung and kidney damage, often leading to death.
- What Causes the Disease?
- What Are the Symptoms?
- How Is Goodpasture Syndrome Diagnosed?
- How Is Goodpasture Syndrome Treated?
The causes of Goodpasture syndrome are not fully understood until now. But there are several factors that may increase the risk of Goodpasture syndrome include:
➢ Exposure to certain chemicals, such as organic solvents (e.g. chloroform, hair dyes), hydrocarbon solvents or the weed killer paraquat
➢ Exposure to metallic dust
➢ Certain drugs, such as cocaine
➢ Smoking
➢ Viral infections
➢ The first signs of Goodpasture syndrome may initially include fatigue, pale skin, shortness of breath and coughing, nausea, vomiting, and weakness. The disease may rapidly involve the lungs, initial symptoms such as shortness of breath can quickly progress to a persistent cough, sometimes with blood.
➢ When Goodpasture syndrome affects the kidneys, symptoms may include blood in the urine or foamy urine, swelling in the legs, burning or difficulty when urinating, back pain below the ribs, and high blood pressure.
➢ Physical examination: checking for high blood pressure, bleeding, and abnormal heart and lung sounds, including an abdominal exam.
➢ Blood test: showing the presence of autoantibodies.
➢ Urine testing: checking for blood cells and proteins in your urine.
➢ X-ray or CT scan: showing signs that indicate lung injury and bleeding in your lungs.
➢ Kidney biopsy: reveal changes (the presence of antibodies or other abnormal cells) in your kidney.
➢ Immunosuppressive medications: keeping your immune system from making the antibodies that damage your lungs and kidneys (such as cyclophosphamide).
➢ Corticosteroid medications: suppressing the body’s autoimmune response and decreasing inflammation (such as prednisone).
➢ Plasmapheresis: removing blood from the body, separating and returning just cells to the patients; the plasma containing anti-GBM antibodies is not returned to the patients.
Common Natural Autoantibody in Goodpasture Syndrome
As an autoimmune disease, Goodpasture syndrome is closely associated with the autoantibodies (mainly anti-glomerular basement membrane autoantibody, anti-GBM) produced by B lymphocytes. They represent diagnostic and/or prognostic markers in affected patients and identify asymptomatic relatives at risk years before disease development. NAA biomarkers to detect and track the progression of Goodpasture syndrome are an unmet clinical need.
- anti-GBM: The main autoantibody occurred in the Goodpasture syndrome, and its target antigen is the alpha-3 chain of type IV collagen.
Fig.1 The possible mechanisms of anti-GBM attack. (L’Imperio, 2017)
What Can We Do at Creative Biolabs?
As a pioneer and undisputed global leader in the rapidly emerging market for in vitro and in vivo NAA analysis, Creative Biolabs has completed numerous NAA detection and analysis projects in different human diseases, including Goodpasture syndrome. we are glad to provide the largest and most diverse portfolio of premade or custom NAA products and services to help you get milestone development. Please do not hesitate to contact us for more information or a detailed quote if you are doing some research on the Goodpasture syndrome.
Reference:
- L’Imperio, V.; et al. Clinicopathological characteristics of typical and atypical anti-glomerular basement membrane nephritis. Journal of Nephrology. 2017, 30(4): 503-509.
Choosing natural autoantibody (NAA) microarray to profile autoantibody repertoire and reveal novel disease's marker.