NAA Service Based on Nephropathy

Natural autoantibodies (NAA) are autoreactive antibodies that arise independently of antigenic or mitogenic stimulation, and contribute to the stimulation of primitive innate system. NAA biomarkers to detect and track the progression of nephropathy are an unmet clinical need. With advanced high-resolution analytical platforms and experienced scientists, Creative Biolabs offers the most diverse portfolio of NAA services to assist our clients in nephropathy diagnosis or immunotherapy. We also provide custom services based on the requirements of our clients to meet the specific demand.

What Is Nephropathy?

Nephropathy is a broad spectrum of renal diseases or renal damages, which can eventually result in kidney failure. Every type of nephropathy can cause a certain extent of kidney dysfunction, which prevents the kidney from excreting any waste products and regulating the water and acid-base balance of the body. So, severe nephropathy may be a potentially fatal condition. The clinical symptoms of nephropathy are diverse, including but not limited to these:

In addition, individual diseases may have their own unique symptoms.

Normal kidney and diseased kidney. Fig.1 Normal kidney morphology and structural changes in diabetes mellitus. (Alicic, et al., 2017)

The Relationship Between Nephropathy and NAA

Several natural autoantibodies have been characterized as associated with renal diseases with some of them being possibly implicated in pathogenesis. Using NAA biomarkers which can either target against kidney-specific autoantigens or against ubiquitous antigens as in systemic autoimmune diseases with renal manifestations to detect or diagnose nephropathy is promising and can reflect clinical responses to immunotherapy. What’s more, autoimmune-mediated damage to the kidneys can be triggered by natural autoantibodies directed against specific proteins or renal structures.

Autoantibodies in pulmonary-renal syndromes. Fig.2 Autoantibodies in pulmonary-renal syndromes. (McCall, 2018)

Common Types of NAA Associated Nephropathies

There are various types of nephrotic syndromes show close associations with natural autoantibodies produced in our body. The analysis of the repertoire of NAAs in nephropathy patients can identify novel, immunogenic protein targets that are highly expressed in the kidney glomerulus and tubules that may bear relevance in the pathogenesis and progression of nephritic diseases. The following is to introduce two well-studied types.

How to Diagnose Nephropathy?

In general, the diagnosis of nephropathy requires a combination of blood tests, imaging examinations, a comprehensive review of the history and symptoms, and a physical examination. There are a series of sophisticated blood detection methods are always used in the clinic, among which, natural autoantibody test can innovatively help to diagnose nephropathy. A variety of highly specific and sensitive autoantibody tests have been developed in the past years and they are currently available to identify autoimmune kidney diseases at an early stage.

What Can We Do at Creative Biolabs?

Creative Biolabs has years of experience in the field of natural autoantibody research. Empowered by our advanced high-resolution analytical platforms and experienced technical team, we have established an NAA library associated with nephropathy from which you can find your interested targets. We also offer a whole set of NAA services to assist our clients in disease diagnose and clinical research. If you are interested, please feel free to contact us for more details.

References:

  1. Alicic, R. Z.; et al. Diabetic kidney disease: challenges, progress, and possibilities. Clinical Journal of the American Society of Nephrology. 2017, 12(12): 2032-2045.
  2. McCall, A.S.; et al. Inhibitory anti-peroxidasin antibodies in pulmonary-renal syndromes. Journal of the American Society of Nephrology. 2018, 29(11): 2619-2625.

Choosing natural autoantibody (NAA) microarray to profile autoantibody repertoire and reveal novel disease's marker.

For Research Use Only | Not For Clinical Use

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