NAA Associated Myocarditis
Myocarditis is a heterogeneous group of disorders defined by inflammation of the heart muscle. Circulating natural autoantibodies (NAA) directed against multiple antigens have been found in myocarditis patients. As a well-recognized leader in the disease diagnosis and with over a decade of experience, Creative Biolabs is dedicated for the research of NAA and we offer our clients with comprehensive high- quality NAA services for scientific research and myocarditis diagnosis.
Introduction of Myocarditis
Myocarditis is an inflammatory disease of the myocardium, diagnosed by endomyocardial biopsy using established immunological, histological, and immunohistochemical criteria. Myocarditis may be idiopathic, infectious or autoimmune and may heal or lead to dilated cardiomyopathy (DCM). In a substantial proportion of patients, myocarditis and DCM represent the acute and chronic stages of an organ-specific autoimmune disease. DCM is featured by dilatation and impaired contraction of the left or both ventricles. The diagnosis of DCM requires exclusion of known, specific causes of heart failure, including coronary artery disease. Numerous interventions have been investigated for the treatment of myocarditis, including broad-spectrum alteration of the immune response and antiviral treatments, however, success is still limited.
Fig.1 Multiphase model of myocarditis. (Heymans, 2016)
As Fig.1 shown, the clinical features of myocarditis are diverse. Myocarditis may be electrocardiograph abnormalities, subclinical, causing minor symptoms such as palpitation, atypical chest pain, or arrhythmias with or without the global or regional left and/or right ventricular dysfunction. Other presentations of myocarditis consist of syncope, sudden death, acute right or left ventricular failure, cardiogenic shock, or DCM.
Common NAA Targets in Myocarditis
Circulating autoantibodies, a peculiar feature of autoimmune disease though not always pathogenic, represent diagnostic and/or prognostic markers in affected patients and identify asymptomatic relatives at risk years before disease development. Several classes of natural autoantibodies with specificity for different types of autoimmune diseases have been described. For example, in myocarditis, there have been identified anti-laminin, anti-MHC, anti-actin, anti-HSP 60/70, anti-tropomyosin, and anti-sarcolemmal antibody, and anti-myolemmal antibody. Here show the targets in myocarditis that could be utilized to offer NAA-related services.
Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for in vitro and in vivo antibody analysis. We currently offer a full range of NAA-related services available for research of a wide variety of diseases, including myocarditis. Please do not hesitate to contact us for more information and a detailed quote.
Reference:
- Heymans, S.; et al. The quest for new approaches in myocarditis and inflammatory cardiomyopathy. Journal of the American College of Cardiology. 2016, 68(21): 2348-2364.
Choosing natural autoantibody (NAA) microarray to profile autoantibody repertoire and reveal novel disease's marker.
- NAA Services for Anti-Sarcolemmal Antibody (ASA)
- NAA Services for Anti-Myolemmal Antibody (AMLA)
- NAA Services for Anti-Fibrillary Antibody (AFA)
- NAA Services for Anti-Interfibrillary (IFA) Antibody
- NAA Services for Anti-laminin Antibody
- NAA Services for Anti-β1 Receptor Antibodies
- NAA Services for Anti-M2 Receptor Antibodies
- NAA Services for Anti-MHC Antibodies
- NAA Services for Anti-HSP 70 Antibodies
- NAA Services for Anti-Tropomyosin Antibodies