Natural Autoantibody Application in Tumor Surveillance
The tumor is one of the most prevailing diseases in the world, which usually leads to cancers even death. Tumor surveillance is a kind of response to tumorigenesis, in which immune surveillance is dominant. As an essential component of the immune system, natural autoantibody (NAA) exerts a pivotal role in immune surveillance or tumor surveillance. As a biological company dedicated to human health research, we Creative Biolabs has devoted ourselves to tumor researches as well as NAA applications for many years. Our objective is to provide the best and professional solutions and services to our customers throughout the world.
Background of Tumor Surveillance
Tumor surveillance in simple terms is that the tumor is identified, subsequently suppressed and even eliminated from cancerous tissues by body-self. Tumor surveillance includes immune and non-immune surveillance. There are at least four different types of non-immune surveillance such as genetic surveillance based on DNA repair and checkpoint control, intracellular surveillance, epigenetic surveillance, and intercellular surveillance. Immune surveillance is a major part of tumor surveillance. It is achieved by a variety of lymphocytes, antibodies, molecules and other factors generated from the immune system, specifically identifying tumor antigen or cancerous cells. Tumor surveillance can help eliminate them before they can cause harm.
Fig.1 Extrinsic tumor suppression by the immune system. (Swann, 2007)
NAA Application in Tumor Surveillance
As an important part of the immune system, NAA has been researched as cancers biomarkers for last few decades. Why NAA is promising in immune surveillance against cancers?
- NAA can recognize both self and non-self antigens at low affinity and specificity;
- Some NAAs are tumor-specific and capable induce lipoapoptosis following accumulation of lipids in cancer cells;
- NAA can bind to cancer cell surface antigens on malignant cells and discriminate early cancer from healthy tissue.
Tumor-associated NAAs are potential biomarkers not only in tumor surveillance but also in early diagnosis prognosis of cancers. NAA related cancers and biomarkers have been investigated by Creative Biolabs for several years. We can provide a series of NAA related research comprising NAA diseases and biomarkers, services, products, and Natural Autoantibody Application to help you get milestone development.
With the research on NAA progresses, in addition to the extensive application for intravenous immunoglobulin, clinical diagnosis, vaccine development, we also find that NAA can be widely used for tumor surveillance. Creative Biolabs also is trying to explore other additional applications of NAA. If you are engaged in NAA reaseaches, or you are interested in the NAA and related applications research, just feel free to contact us for more detailed communications and information. We are more than happy to share our experience and help our customers in related researches.
Reference:
- Swann, J.B.; Smyth, M.J. Immune surveillance of tumors. The Journal of Clinical Investigation. 2007, 117(5):1137-1146.