NAA Associated Thyroiditis
Increasing evidence has shown the association between thyroiditis and the presence of natural autoantibodies (NAA) in the last few years. Creative Biolabs is a world’s leading service provider for comprehensive customized NAA detection and analysis services to accelerate the study of pathogenesis and promote the therapy of thyroiditis disease. We offer tailored solutions and advanced platforms for NAA services to facilitate disease diagnosis and treatment, as well as any other clinical research.
Introduction of Thyroiditis
Thyroiditis is also known as "inflammation of the thyroid gland". The thyroid gland is located on the front of the neck below the laryngeal prominence and produces hormones to mediate a variety of metabolism pathways. Thyroiditis is a group of endocrine disorders that lead to thyroidal inflammation. Hashimoto's thyroiditis is the most common cause of hypothyroidism, postpartum thyroiditis, subacute thyroiditis, silent thyroiditis, drug-induced thyroiditis, radiation-induced thyroiditis, acute thyroiditis, and Riedel's thyroiditis.
Fig.1 Effects of thyroid hormones in normal and pathologic conditions. (Salazar, et al., 2019)
Symptoms and Signs of Thyroiditis
Common hypothyroid symptoms are present when thyroid cells are slow and chronically damaged, including the fatigue, weight gain, feeling "fuzzy-headed", depression, dry skin, and constipation. In addition, some rarer symptoms include swelling of the legs, vague aches and pains, decreased concentration and so on. When conditions become more severe, symptoms start to show the puffiness around the eyes, slowing of the heart rate, a drop in body temperature, or even incipient heart failure. When the thyroid cell damage is acute, the thyroid hormone within the gland leaks out into the bloodstream causing symptoms of thyrotoxicosis, these symptoms include weight loss, irritability, anxiety, insomnia, fast heart rate, and fatigue, which is similar to those of hyperthyroidism. But, it is different from hyperthyroidism because the thyroid gland is not overactive.
Causes and Pathogenesis
Thyroiditis is generally caused by an immune system attack on the thyroid, leading to inflammation and the thyroid cells damage. This disease is often considered as a dysfunction of the immune system, which is associated with the IgG4-related systemic disease. Inflammation in the thyroid tissue is happened, which can extend to neighboring structures. Autoantibodies attack thyroid induces the most types of thyroiditis, so, it is also considered as an autoimmune disease. It can be also caused by an infection, such as a virus or bacterial infection, which occurs in the same way because of the glands inflammation caused by autoantibodies, such as in the case of subacute granulomatous thyroiditis. Some drugs, such as interferon, lithium, and amiodarone, can also induce thyroiditis because they have a tendency to damage thyroid cells.
Common NAA Targets Based Thyroiditis
The thyroiditis disease is always combined with the production of some autoantibodies (NAA), therefore, the detection and analysis of NAA can be regarded as an indication to support the diagnosis of thyroiditis. In addition, a series of therapeutics aimed at the NAA can be designed according to the results of NAA detection. To date, there are four targets have been recognized in thyroiditis disease:
| Natural Autoantibodies Targets in Thyroiditis | |||
| Anti-TPO Antibodies | Anti-TSH Receptor | Anti-Thyroglobulin | Anti-Na+/I− Symporter |
NAA Detection Associated with Thyroiditis
In general, self-reactive immunity serves as the defensive line of the body in normal state and disease. During the self-reactive immune responses, some antibodies presenting in the sera of healthy individuals are considered natural autoantibodies (NAA), which react with a variety of endogenous and exogenous antigens. IgM isotype natural autoantibodies, which play an important role in the enhancement of innate immunity, can prevent pathogenic processes and maintain or restore health status. However, the IgG isotypes are pathogenic autoantibodies causing autoimmune diseases. Therefore, the NAA detection and analysis are required in medicine development and diseases diagnosis, as well as appropriate therapeutic intervention in autoimmune and malignant diseases such as the thyroiditis.
Advantages of Our Services
- A full range of services from NAA detection to disease treatment
- A wide variety of methods for clinical presentation or diagnosis
- Experienced scientists and first-class platforms provide the best service
- The most competitive prices in the industry
Creative Biolabs is dedicated to providing high-quality NAA services related to all kinds of NAA associated diseases, including thyroiditis. Our professional scientists have over decades of experience and have successfully completed a range of projects specifically tailored to antibody analytics. Our high-quality products and services will contribute greatly to the success of your projects. Please feel free to contact us for more information and a detailed quote.
Reference:
- Salazar, P.; et al. Hypothyroidism and cognitive disorders during development and adulthood: implications in the central nervous system. Molecular neurobiology. 2019, 56(4): 2952-2963.
Choosing natural autoantibody (NAA) microarray to profile autoantibody repertoire and reveal novel disease's marker.
- NAA Services for Anti-TPO Antibodies
- NAA Services for Anti-TSH Receptor
- NAA Services for Anti-Thyroglobulin Antibody
- NAA Services for Anti-Na+/I- Symporter Antibody