Human Glomerular basement membrane (GBM) Autoantibody (IgG) ELISA kit (CAT#: NAK-045)

This product is an ELISA kit for the determination of Glomerular basement membrane (GBM) Autoantibody in human Plasma or Serum. It is highly sensitive and available for the detection of Glomerular basement membrane (GBM) Autoantibody as low as 1.0 U/mL (0 to 200 U/mL).

Specifications
Sensitivity	1.0 U/mL (0 to 200 U/mL)
Assay Type	ELISA
Pack size	1×96 wells
Species Reactivity	Human
Antibody Type	IgG
Contents	Divisible microplate Calibrators (A-F) Control positive IgG (1) Control positive IgA (2) Sample buffer P (5x) Enzyme Conjugate TMB substrate Stop solution Wash solution (50x)
Sample Requirement	Plasma, Serum: 100ul
Storage	Short term: 4°C, Long term: See manual.

Target Information
Target	Glomerular basement membrane (GBM) autoantibody
Introduction	The glomerular basement membrane (GBM) is the extracellular matrix component of the selectively permeable glomerular filtration barrier (GFB) that separates the vasculature from the urinary space. The GBM lies between, and is initially synthesized by, the glomerular endothelial cells that line the glomerular capillaries and the podocytes (also called visceral epithelial cells) that sit on the opposite side of the GBM within the urinary space. This three-layered structure-endothelium, GBM, and podocyte-facilitates the flow of plasma water and small solutes while restricting the flow of large plasma proteins such as albumin. The presence of high levels of albumin in the urine is considered to be indicative of a defect in at least one of the layers of the GFB.

Target Information

Target

Glomerular basement membrane (GBM) autoantibody

Introduction

The glomerular basement membrane (GBM) is the extracellular matrix component of the selectively permeable glomerular filtration barrier (GFB) that separates the vasculature from the urinary space. The GBM lies between, and is initially synthesized by, the glomerular endothelial cells that line the glomerular capillaries and the podocytes (also called visceral epithelial cells) that sit on the opposite side of the GBM within the urinary space. This three-layered structure-endothelium, GBM, and podocyte-facilitates the flow of plasma water and small solutes while restricting the flow of large plasma proteins such as albumin. The presence of high levels of albumin in the urine is considered to be indicative of a defect in at least one of the layers of the GFB.

Customer Reviews
Downloadable Resources

Click the button below to contact us or submit your feedback about this product.

Datasheet

For Research Use Only | Not For Clinical Use

Services:

Resource:

Pathways

Applications:

Online Inquiry