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Anti-TPBG (clone A1)-SMCC-DMA ADC (ADC-W-005)

This ADC product is comprised of an anti-TPBG monoclonal antibody (clone A1) conjugated via a SMCC linker to DMA. The DMA is targeted to TPBG-positive cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.
  • Antibody clone #
  • A1

 ADC Target

  • Name
  • TPBG
  • Alternative Names
  • M6P1; TPBGAG; WAIF1; TPBG oncofetal antigen; TPBG oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; TPBG oncofetal trophoblast glycoprotein;
  • Target Entrez Gene ID
  • 7162
  • Overview
  • This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.

 ADC Antibody

  • Overview
  • Humanized Anti-TPBG IgG1 antibody, clone # A1
  • Clone #
  • A1
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
  • Description
  • Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

 ADC payload drug

  • Name
  • DMA (dimethylacetamide)

For Research Use Only. NOT FOR CLINICAL USE.

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