Anti-ER-a36 (clone SNGmBI)-SPDB-DM4 ADC (ADC-W-206)

This ADC product is comprised of an anti-ER-a36 monoclonal antibody (clone SNGmB) conjugated via a SPDB linker to DM4. The DM4 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM4 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
  • Antibody clone #
  • SNGmBI

 ADC Target

  • Name
  • ER-a36
  • Alternative Names
  • ER; ESR; Era; ESRA; ESTRR; NR3A1
  • Target Entrez Gene ID
  • 2099
  • Overview
  • This gene is a 36 kDa variant of hER-a, it lacks the N-terminal AF-1 domain and the C-terminal AF-2 domain of hER-a. hER-a is one of the two types of estrogen receptors discovered in human cells (hERs). hERs encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.

 ADC Antibody

  • Overview
  • Anti-ER-a36 mlgG2b antibody, clone # SNGmBI
  • Clone #
  • SNGmBI
  • Host animal
  • Mouse
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)

 ADC payload drug

  • Name
  • DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
  • Description
  • Derived from Maytansinoid,a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

For Research Use Only. NOT FOR CLINICAL USE.


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