What is alpha-Amanitin used for in biological research?

Alpha-Amanitin is a potent inhibitor of RNA polymerase II, widely used in research to study transcription processes, gene regulation, and the effects of transcription inhibition in eukaryotic cells.

What is the origin of alpha-Amanitin used by Creative Biolabs?

Creative Biolabs provides alpha-Amanitin derived from fungal fermentation. This method ensures a high-purity product suitable for use in transcription inhibition studies and other research applications.

What is the effect of alpha-Amanitin on different cell types?

Alpha-Amanitin selectively inhibits RNA polymerase II, affecting only eukaryotic cells. Prokaryotic cells, which lack RNA polymerase II, are generally unaffected, making it useful for selective transcription studies in eukaryotes.

Can alpha-Amanitin be used in conjunction with other transcription inhibitors?

Yes, alpha-Amanitin is often used with other transcription inhibitors to dissect different stages of transcription and understand the complex regulatory mechanisms controlling gene expression in eukaryotic cells.

What are the research cases of α-amanitin as an ADC toxin?

Research has explored α-amanitin as an ADC toxin, such as a study using anti-EpCAM antibodies conjugated with α-amanitin in treating EpCAM-positive cancers. Another case involved its conjugation with HER2-targeted antibodies, demonstrating effectiveness against HER2-positive breast cancer cells.

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alpha-Amanitin - fungal fermentation origin

alpha-Amanitin - fungal fermentation origin (CAT#: ADC-P-107)

ADCs Toxins, alpha-Amanitin, a peptide, consisting of eight amino acids.The source of this specific alpha-Amanitin is fungal fermentation. By this production method the supply problems are solved. alpha-Amanitin is an inhibitor of RNA polymerase II (0.02 micrograms/ml). RNA polymerase I was also inhibited by the relatively high concentration of alpha-amanitin (IC50 = 100 micrograms/ml and IC70 = 750 micrograms/ml).

Product Information

CAS NO
23109-05-9

Description
ADCs Toxins, alpha-Amanitin, a peptide, consisting of eight amino acids.The source of this specific alpha-Amanitin is fungal fermentation. By this production method the supply problems are solved. alpha-Amanitin is an inhibitor of RNA polymerase II (0.02 micrograms/ml). RNA polymerase I was also inhibited by the relatively high concentration of alpha-amanitin (IC50 = 100 micrograms/ml and IC70 = 750 micrograms/ml).

Classification
RNA inhibitors

Molecular Weight
918.97

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

We utilized alpha-Amanitin from Creative Biolabs in our toxin-based research, and it performed exceptionally well. The high-quality product provided strong inhibition of RNA polymerase, making it a valuable addition to our experiments.

Excellent

Alpha-Amanitin from Creative Biolabs proved to be a powerful inhibitor in our studies. Its fungal fermentation origin ensured excellent purity and potency, delivering reliable results in our cancer research.

Excellent

Creative Biolabs' alpha-Amanitin worked effectively in our lab, allowing us to successfully inhibit RNA polymerase in various experimental settings. The product was easy to handle and integrate into our workflow.

Excellent

Alpha-Amanitin from Creative Biolabs supported our research on RNA transcription mechanisms. It helped us explore complex pathways and provided a deeper understanding of cellular processes.

Excellent

We incorporated alpha-Amanitin from Creative Biolabs into our experiments, and it performed very well. Its reliable inhibitory effects were invaluable in advancing our research on cellular responses.

Q: 1: What is alpha-Amanitin used for in biological research?
A: Alpha-Amanitin is a potent inhibitor of RNA polymerase II, widely used in research to study transcription processes, gene regulation, and the effects of transcription inhibition in eukaryotic cells.
Q: 2: What is the origin of alpha-Amanitin used by Creative Biolabs?
A: Creative Biolabs provides alpha-Amanitin derived from fungal fermentation. This method ensures a high-purity product suitable for use in transcription inhibition studies and other research applications.
Q: 3: What is the effect of alpha-Amanitin on different cell types?
A: Alpha-Amanitin selectively inhibits RNA polymerase II, affecting only eukaryotic cells. Prokaryotic cells, which lack RNA polymerase II, are generally unaffected, making it useful for selective transcription studies in eukaryotes.
Q: 4: Can alpha-Amanitin be used in conjunction with other transcription inhibitors?
A: Yes, alpha-Amanitin is often used with other transcription inhibitors to dissect different stages of transcription and understand the complex regulatory mechanisms controlling gene expression in eukaryotic cells.
Q: 5: What are the research cases of α-amanitin as an ADC toxin?
A: Research has explored α-amanitin as an ADC toxin, such as a study using anti-EpCAM antibodies conjugated with α-amanitin in treating EpCAM-positive cancers. Another case involved its conjugation with HER2-targeted antibodies, demonstrating effectiveness against HER2-positive breast cancer cells.

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