This product is comprised of an Humanized Anti-IFNG IgG1 antibody (Clone 1) labeled with iFluor® 488 Succinimidyl Ester. iFluor® 488 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
- Overview
- GD2 is a disialic ganglioside expressed in tumors of neuroectodermal origin (including human neuroblastoma and melanoma), and its expression in normal tissues (mainly human cerebellum and peripheral nerves) is highly restricted.
The relative tumor-specific expression of GD2 makes it a suitable target for immunotherapy using monoclonal antibodies or artificial T cell receptors. An example of such an antibody is hu14.18K322A, a monoclonal antibody. The anti-GD2 antibody is currently in phase II clinical trials for the treatment of previously untreated high-risk neuroblastoma and combined chemotherapy prior to stem cell transplantation and radiation therapy. A previous phase I clinical trial designed to reduce toxicity in patients with refractory or recurrent neuroblastoma found a safe dose and determined that common toxicity, especially pain, can be well controlled.
ANTIBODY
- Overview
- Humanized Anti-IFNG IgG1 antibody (Clone 1)
DYE
- Name
- iFluor® 488 Succinimidyl Ester
- Excitation⁄Emission (nm)
- 491/516
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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