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- Anti-IFNG MAb (Clone 2)-iFluor® 350 Succinimidyl Ester
Anti-IFNG MAb (Clone 2)-iFluor® 350 Succinimidyl Ester (CAT#: WJY0-LS1280)
- TARGET
- ANTIBODY
- DYE
- Name
- IFNG
- Alternative Names
- GD2
- Overview
- GD2 is a disialoganglioside expressed in tumors of neuroectodermal origin (including human neuroblastoma and melanoma), and its expression in normal tissues (mainly human cerebellum and peripheral nerves) is highly restricted.
The relative tumor-specific expression of GD2 makes it a suitable target for immunotherapy using monoclonal antibodies or artificial T cell receptors. An example of such an antibody is hu14.18K322A, a monoclonal antibody. The anti-GD2 antibody is currently in phase II clinical trials for the treatment of previously untreated high-risk neuroblastoma and combined chemotherapy prior to stem cell transplantation and radiation therapy. A previous phase I clinical trial designed to reduce toxicity in patients with refractory or recurrent neuroblastoma found a safe dose and determined that common toxicity, especially pain, can be well controlled.
- Overview
- Human Anti-IFNG IgG1-lambda (Clone 2)
- Species Reactivity
- Human
- Name
- iFluor® 350 Succinimidyl Ester
- Color
- Blue
- Excitation⁄Emission (nm)
- 345/450
- Detection method
- Fluorescent
Published Data
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Other Products
Same Target
| CAT# | Product Name | Linker | Payload |
| ADC-W-1230 | Anti-IFNG (Crenezumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-1228 | Anti-IFNG (Crenezumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1229 | Anti-IFNG (Crenezumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1226 | Anti-IFNG (Crenezumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-1231 | Anti-IFNG (Crenezumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
For Research Use Only. NOT FOR CLINICAL USE.
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