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- Anti-IL23A MAb (Clone 2)-iFluor® 430 Succinimidyl Ester
Anti-IL23A MAb (Clone 2)-iFluor® 430 Succinimidyl Ester (CAT#: WJY0-LS3704)
This product is comprised of an Humanized Anti-IL23A IgG1-kappa antibody (Clone 2) labeled with iFluor® 430 Succinimidyl Ester. iFluor® 430 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- IL23A
- Alternative Names
- IL23A; IL-23; IL-23A; IL23P19; P19; SGRF; Interleukin 23; interleukin 23 subunit alpha
- Overview
- IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration into tumours. IL-23 mediates its effects on both innate and adaptive arms of the immune system that express the IL-23 receptor. Th17 cells represent the most prominent T cell subset that responds to IL-23, although IL-23 has been implicated in inhibiting the development of regulatory T cell development in the intestine. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of other proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.
- Overview
- Humanized Anti-IL23A IgG1-kappa antibody (Clone 2)
- Species Reactivity
- Human
- Name
- iFluor® 430 Succinimidyl Ester
- Color
- Green
- Excitation⁄Emission (nm)
- 433/498
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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| CAT# | Product Name | Linker | Payload |
| ADC-W-1356 | Anti-IL23A (Tildrakizumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-1347 | Anti-IL23A (Guselkumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-1357 | Anti-IL23A (Tildrakizumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-1354 | Anti-IL23A (Tildrakizumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1348 | Anti-IL23A (Guselkumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
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