Anti-IL5 MAb (Clone 2)-iFluor® 546 Succinimidyl Ester (WJY0-LS14477)

This product is comprised of an Humanized Anti-IL5 IgG2 antibody (Clone 2) labeled with iFluor® 546 Succinimidyl Ester. iFluor® 546 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.

TARGET

Name
IL5

Alternative Names
Eosinophil differentiation factor; EDF; IL-5; TRF; T-cell replacing factor; B-cell differentiation factor I; Interleukin-5

Overview
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.

ANTIBODY

Overview
Humanized Anti-IL5 IgG2 antibody (Clone 2)

Species Reactivity
Human

DYE

Name
iFluor® 546 Succinimidyl Ester

Color
Green

Excitation⁄Emission (nm)
541/557

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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