Anti-ITGAV MAb (Clone 1)-iFluor® 430 Succinimidyl Ester
Anti-ITGAV MAb (Clone 1)-iFluor® 430 Succinimidyl Ester (WJY0-LS3370)
This product is comprised of an Anti-ITGAV antibody (Clone 1) labeled with iFluor® 430 Succinimidyl Ester. iFluor® 430 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
Name
ITGAV
Alternative Names
ITGAV; CD51; MSK8; VNRA; VTNR; integrin subunit alpha V
Overview
ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.