- Home
- Products
- Customized ADCs
- NOTCH3
- Anti-NOTCH3-MMAE ADC
Anti-NOTCH3-MMAE ADC (CAT#: ADC-W-559)
This ADC product is comprised of an anti-NOTCH3 monoclonal antibody conjugated via a linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- ADC Target
- ADC Antibody
- ADC payload drug
- Name
- NOTCH3
- Alternative Names
- notch 3; IMF2; CASIL; CADASIL; neurogenic locus notch homolog protein 3; Notch homolog 3;
- Target Entrez Gene ID
- 4854
- Target UniProt ID
- Q9UM47
- Overview
- This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
- Overview
- Anti-NOTCH3 Antibody
- Species Reactivity
- Human
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-CXCL10 (Eldelumab)-SMCC-DM1 ADC (CAT#: ADC-W-1010)
- Anti-RSV (Felvizumab)-SPDB-DM4 ADC (CAT#: ADC-W-2001)
- Anti-FOLR1-DGN462 ADC (CAT#: ADC-W-562)
- Anti-EGFR (Zalutumumab)-MC-MMAF ADC (CAT#: ADC-W-2585)
- Anti-TGFB1 (Metelimumab)-SPDB-DM4 ADC (CAT#: ADC-W-1803)
- Anti-Adenocarcinoma antigen-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-2119)
- Anti-BSG (Ziralimumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-726)
- Anti-PVRL4 (Enfortumab vedotin)-SPDB-DM4 ADC (CAT#: ADC-W-2397)
- Anti-TMEFF2-Mc-VC-PABC-MMAE ADC (CAT#: ADC-W-437)
- Anti-FCER2 (Lumiliximab)-SMCC-DM1 ADC (CAT#: ADC-W-1136)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-559. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-017 | anti-HIgG(Fab)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-W-536 | Anti-EDNRB (endothelin B)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-462 | Anti-GPNMB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-011 | anti-HIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
