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Anti-EGFR-S-3AA-MDC ADC-2 (CAT#: ADC-W-126)

This ADC product is comprised of an anti-EGFR monoclonal antibody (clone Bat0206) conjugated via a S-3AA linker to MDC. The MDC is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MDC binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • Bat0206
  • Name
  • EGFR
  • Alternative Names
  • epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian
  • Target Entrez Gene ID
  • 1956
  • Overview
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
  • Overview
  • Anti-EGFR antibody, clone # Bat0206
  • Clone #
  • Bat0206
  • Species Reactivity
  • Human
  • Name
  • S-3AA
  • Name
  • MDC (maytansinol)
  • Description
  • Derived from Maytansinoid,a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform
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CAMouse™-Fully Human Antibody Generation Platform
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ADC-W-127 Anti-EGFR-SMCC-MDC ADC-2 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) MDC (maytansinol)

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