Linker-Toxin SET, This set is made by SN38 conjugated to a maleimide-type cathepsine-B-cleavable dipeptide Phe-Lys linker ( containing a triazoline group and a spacer PEG (n=8) ). SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.
- Description
- Linker-Toxin SET, This set is made by SN38 conjugated to a maleimide-type cathepsine-B-cleavable dipeptide Phe-Lys linker ( containing a triazoline group and a spacer PEG (n=8) ). SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.
For Research Use Only. NOT FOR CLINICAL USE.
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