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- Farletuzumab-iFluor 680
Farletuzumab-iFluor 680 (CAT#: ADC-FL-1540)
This product is comprised of an anti-FOLH1 monoclonal antibody (Farletuzumab) labeled with iFluor 680. iFluor 680 is a near-IR-fluorescent dye and it's excitation/emission is 679/702 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- FOLR1
- Alternative Names
- FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; FOLH; glutamate carboxypeptidase 2; GCP2; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; NAALAD1; NAALAdase; PSM; PSMA; NAALADase I; membrane glutamate carboxypeptidase; cell
- Overview
- This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
- Overview
- Humanized Anti-FOLR1 IgG1-kappa antibody, Farletuzumab
- Generic name
- Farletuzumab
- Species Reactivity
- Human
- Name
- iFluor 680
- Color
- Near-IR
- Excitation⁄Emission (nm)
- 679/702
- Detection method
- Fluorescent
Published Data
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Other Products
Same Target
| CAT# | Product Name | Linker | Payload |
| ADC-W-602 | Anti-FOLR1-S-S-Dox ADC | disulfide (“S-S”) linker | doxorubicin |
| ADC-W-1171 | Anti-FOLR1 (Farletuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-1169 | Anti-FOLR1 (Farletuzumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1166 | Anti-FOLR1 (Farletuzumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-1167 | Anti-FOLR1 (Farletuzumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
For Research Use Only. NOT FOR CLINICAL USE.
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