Anti-158P1D7 (clone Hal5-10acl2)-VC-MMAE ADC (ADC-W-016)

This ADC product is comprised of an anti-158P1D7 monoclonal antibody (clone Hal5-10acl2) conjugated via a VC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
  • Antibody clone #
  • Hal5-10acl2

 ADC Target

  • Name
  • 158P1D7
  • Overview
  • 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or its encoded protein or a fragment thereof, can be used to elicit an immune response.

 ADC Antibody

  • Overview
  • Chimeric Anti-158P1D7 antibody, clone # Hal5-10acl2
  • Clone #
  • Hal5-10acl2
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • VC (valine-citrulline)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • MMAE (Monomethyl auristatin E)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.


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