Anti-CD33 (clone hP67.6)-AcBut-Calicheamicin ADC (ADC-W-464)

This ADC product is comprised of an Anti-CD33 antibody (clone hP67.6) conjugated via a AcBut linker to Calicheamicin. The Calicheamicin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, Calicheamicin binds to DNA, causes DNA damage.
  • Antibody clone #
  • hP676
  • Similar to
  • gemtuzumab ozogamicin

 ADC Target

  • Name
  • CD33
  • Alternative Names
  • CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;
  • Target Entrez Gene ID
  • 945
  • Overview
  • CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

 ADC Antibody

  • Overview
  • Anti-CD33 lgG4κ Antibody, clone # hP676
  • Generic name
  • gemtuzumab
  • Clone #
  • hP676
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • AcBut (4-(4-acetylphenoxy)butanoic acid)
  • Description
  • Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.

 ADC payload drug

  • Name
  • Calicheamicin
  • Description
  • Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

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