Mc-vc-PAB-SN38 (ADC-S-023)

Linker-Toxin SET, this set is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.
  • Description
  • Linker-Toxin SET, this set is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.
  • Molecular Weight
  • 991.07
  • Purity
  • 95%

For Research Use Only. NOT FOR CLINICAL USE.


Related Products


Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:









Customized FluoroAb™

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA
 
 Tel:
 Fax:
 Email:
Europe
 
 Tel:
 Email:
Germany
 
 Tel:
 Email:


Inquiry

Top