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Mc-vc-PAB-SN38 (CAT#: ADC-S-023)
Linker-Toxin SET, this set is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.
- Product Information
- Description
- Linker-Toxin SET, this set is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.
- Molecular Weight
- 991.07
- Purity
- 95%
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