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- Sibrotuzumab-iFluor 405
Sibrotuzumab-iFluor 405 (CAT#: ADC-FL-1424)
- TARGET
- ANTIBODY
- DYE
- Name
- FAP
- Alternative Names
- FAP; fibroblast activation protein, alpha; seprase; DPPIV; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; FAPA; DKFZp686G13158;
- Overview
- The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Overview
- Humanized Anti-FAP IgG1-kappa antibody, Sibrotuzumab
- Generic name
- Sibrotuzumab
- Species Reactivity
- Human
- Name
- iFluor 405
- Color
- Blue
- Excitation⁄Emission (nm)
- 401/421
- Detection method
- Fluorescent
Published Data
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Scientific Resources
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Other Products
Same Target
| CAT# | Product Name | Linker | Payload |
| ADC-W-1130 | Anti-FAP (Sibrotuzumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-593 | Anti-FAP-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-1132 | Anti-FAP (Sibrotuzumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1134 | Anti-FAP (Sibrotuzumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-1133 | Anti-FAP (Sibrotuzumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
For Research Use Only. NOT FOR CLINICAL USE.
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