SPDB-DM4 (CAT#: ADC-S-010)
Linker-Toxin SET, Linker-Toxin SET, This set is made by DM4 conjugated to SPDB linker. DM4 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells. SPDB, a disulfide linker, is extensively exploited as a chemically labile linkage.
- Product Information
- Description
- Linker-Toxin SET, Linker-Toxin SET, This set is made by DM4 conjugated to SPDB linker. DM4 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells. SPDB, a disulfide linker, is extensively exploited as a chemically labile linkage.
- Molecular Weight
- 780.4
- Purity
- 95%
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