Tacatuzumab-Fluoresein (ADC-FL-034)

This product is comprised of an anti-AFP monoclonal antibody (Tacatuzumab) labeled with Fluoresein. Fluoresein is a fluorescent dye and it's excitation/emission is 490/525 nm.

 TARGET

  • Name
  • AFP
  • Alternative Names
  • AFP; alpha-fetoprotein; HPAFP; FETA; alpha-fetoglobulin; alpha-1-fetoprotein;
  • Overview
  • This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

 ANTIBODY

  • Overview
  • Humanized Anti-AFP IgG1-kappa antibody, Tacatuzumab
  • Generic name
  • Tacatuzumab
  • Species Reactivity
  • Human

 DYE

  • Name
  • Fluoresein
  • Excitation⁄Emission (nm)
  • 490/525

For Research Use Only. NOT FOR CLINICAL USE.


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