ACVR2B

Activin type 2B receptor (ACVR2B) also known as TX4, ACTRIIB or ActR-IIB, it is encoded by the ACVR2B gene. Activins are members of the transforming growth factor-beta (TGF-beta) superfamily, and they are dimeric growth and differentiation factors. Activins function by a heteromeric complex of receptor serine kinases which comprise more than two type I (I and IB) and two type II (II and IIB) receptors. All these receptors are transmembrane proteins, made up of a ligand-binding extracellular domain with the cysteine-rich region, a cytoplasmic domain with predicted serine/threonine specificity, as well as a transmembrane domain. Among them, the type I receptors are crucial for signaling, while the type II receptors are necessary for binding ligands and for expression of type I receptors. However, after ligand binding, type I and II receptors can generate a stable complex, leading to the phosphorylation of type I receptors by type II receptors.
Activins are expressed in a variety of tissues and have a great number of activities, such as hormonal homeostasis, regulation of gonadal function, regulation of growth and metastasis of cancer cells, as well as proliferation and differentiation of embryonic stem cells. Basically, ACVR2B protein is ideal for investigators involved in signaling proteins, cellular proteins, cancer, and ser/thr kinase research.
Gene ID: 93
UniProt ID: Q13705