CCR5

C-C chemokine receptor type 5 (CCR5), also known as CKR5, CD195, or CMKBR5, is a seven transmembrane G protein-coupled receptor and belongs to beta-chemokine receptors family. It functions as a chemokine receptor involved in inflammatory responses. CCR5 has been revealed to regulate the CC-chemotaxis of leucocytes to inflammation sites and involve the recruitment of macrophages, monocytes, and T cells in inflammation. Besides, CCR5 also act as a co-receptor for macrophage-tropic virus including HIV. It can aid HIV to enter host cells. And the variants in CCR5 may lead to HIV infection resistance. Additionally, the expression of CCR5 is detected in a promyeloblastic cell line, indicating it may exert a role in granulocyte lineage proliferation and differentiation.
CCR5 is mostly expressed on T cells, macrophages, dendritic cells, eosinophils, and microglia. And the high level of CCR5 is also found in many types of tumor cells such as breast cells and prostate cancer cells. Studies have been shown that CCR5 is involved in the progression of different types of malignant tumors through indirectly regulating the antitumor immune response. Moreover, CCR5 has been regarded as a promising target for tumor immunotherapy. And CCR5 antagonists are the effective drugs to inhibit tumor growth and migration.
Gene ID: 1234
UniProt ID: P51681