CD70

CD70, also known as CD27L, CD27-L, CD27LG, TNFSF7, or TNLG8A, is a cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is a type II transmembrane protein containing 193 amino acids with a molecular weight of ~50 kDa. CD70 is a ligand for TNFRSF27 (CD27) and the interaction between CD70 and CD27 is crucial for T-cell activation, costimulated T-cells proliferation, and cytolytic T-cell generation. CD70 is also reported to participate in B-cell activation.

CD70 is essentially absent in normal non-lymphoid tissues while its constitutive expression is observed in many hematological malignancies and solid tumors. High level CD70 expression has been documented in lymphomas, renal cell carcinoma (RCC), nasopharyngeal carcinoma, and Epstein-Barr virus-induced carcinomas while the expression level of CD27, its receptor, also showed positive correlation to that of CD70 in some cases. CD70 has become an active target for immunotherapy development. Current therapies against CD70-bearing cancer cells include antibody-induced ADCC, ADC, and antibody-mediated CD70 blockage.

Entrez Gene ID: 970
UniProt ID: P32970

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-080 Anti-CD70 (clone 1F6)-VC-MMAE ADC Anti-CD70 antibody, clone # 1F6 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-081 Anti-CD70 (clone 1F6)-VC-AFP ADC Anti-CD70 antibody, clone # 1F6 VC (valine-citrulline) AFP (dimethylvaline-valine-dolaisoleuine-dolaproine-phenylalanine-p-phenylenediamine) Inquiry
ADC-W-082 Anti-CD70 (clone 1F6)-VC-MMAF ADC Anti-CD70 antibody, clone # 1F6 VC (valine-citrulline) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-451 Anti-CD70 (clone 1F6)-Mc-VC-PABC-MMAF ADC Anti-CD70 Antibody, clone # 1F6 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-452  Anti-CD70 (clone 1F6)-Mc-MMAF ADC Anti-CD70 Antibody, clone # 1F6 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-083 Anti-CD70 (clone 2F2)-VC-MMAE ADC Anti-CD70 antibody, clone # 2F2 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-084 Anti-CD70 (clone 2F2)-VC-AFP ADC Anti-CD70 antibody, clone # 2F2 VC (valine-citrulline) AFP (dimethylvaline-valine-dolaisoleuine-dolaproine-phenylalanine-p-phenylenediamine) Inquiry
ADC-W-085 Anti-CD70 (clone 2F2)-VC-MMAF ADC Anti-CD70 antibody, clone # 2F2 VC (valine-citrulline) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-446 Anti-CD70 (clone h1F6)-Mc-VC-PBD ADC Anti-CD70 Antibody, clone # H1f6 mc-VC (maleimidocaproyl-valine-citrulline) pyrrolobenzodiazepine (PBD) dimers Inquiry
ADC-W-573 Anti-CD70 (clone h1F6239C)-PBD ADC Anti-CD70 Antibody, clone # h1F6239C maleimidocaproyl-valine-alanine pyrrolobenzodiazepine (PBD) Inquiry
ADC-W-587 Anti-CD70 (clone h1F6 )-Mc-VC-PABC-MMAE ADC Anti-CD70 IgG1 Antibody, clone # h1F6 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-471  Anti-CD70-VC-MED-2460-ADC MDX-1203 Human Anti-CD70 lgG1 Antibody VC (valine-citrulline) MED-2460 Inquiry
ADC-W-487  Anti-CD70-MCC-DM1 ADC AMG-172 Human Anti-CD70 lgG1 Antibody MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-567 Anti-CD70-DM1 ADC Human Anti-CD70 lgG1 Antibody Noncleavable thioether linker DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-950 Anti-CD70 (Vorsetuzumab)-SMCC-DM1 ADC Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-951 Anti-CD70 (Vorsetuzumab)-SPDB-DM4 ADC Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-952 Anti-CD70 (Vorsetuzumab)-MC-MMAF ADC Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-953 Anti-CD70 (Vorsetuzumab)-MC-Vc-PAB-MMAE ADC Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-954 Anti-CD70 (Vorsetuzumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-955 Anti-CD70 (Vorsetuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-369 Anti-CD70 (clone c1F6)-val-cit-PABC-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # C1f6 VC-PABC (valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-370 Anti-CD70 (clone h1F6)-α-glucuronide-MMAE ADC Humanized Anti-CD70 lgG1 Antibody, clone # C1f6 α-glucuronide MMAE (Monomethyl auristatin E) Inquiry
ADC-W-371 Anti-CD70 (clone h1F6)-α-glucuronide-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # C1f6 α-glucuronide MMAF (Monomethyl auristatin F) Inquiry
ADC-W-366 Anti-CD70 (clone c1F6)-VC-AFP ADC Humanized Anti-CD70 lgG1 Antibody, clone # C1f6 VC (valine-citrulline) AFP (auristatin phenylalanine phenylenediamine) Inquiry
ADC-W-367 Anti-CD70-VC-rachelmycin ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1f6 VC (valine-citrulline) CC-1065 (rachelmycin) Inquiry
ADC-W-368 Anti-CD70 (clone h1F6)-VC-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1f6 VC (valine-citrulline) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-365 Anti-CD70 (clone h1F6)-VC-AFP ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1f6 VC (valine-citrulline) AFP (auristatin phenylalanine phenylenediamine) Inquiry
ADC-W-372 Anti-CD70 (clone h1F6)-β-glucuronide-Camptothecin Analog ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1f6 β-glucuronide linker Camptothecin Analog Inquiry
ADC-W-373 Anti-CD70 (clone h1F6)-β-glucuronide-CBI Minor Groove Binder ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1f6 β-glucuronide linker CBI Minor Groove Binder Inquiry
ADC-W-374 Anti-CD70 (clone h1F6)-β-glucuronide-MMAE ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1f6 β-glucuronide linker MMAE (Monomethyl auristatin E) Inquiry
ADC-W-375 Anti-CD70 (clone h1F6)-β-glucuronide-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1f6 β-glucuronide linker MMAF (Monomethyl auristatin F) Inquiry
ADC-W-376 Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1f6 β-glucuronide linker doxorubicin Inquiry
ADC-W-236 Anti-CD70 (clone h1F6 C4v2)-Mc-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1F6 C4v2 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-361 Anti-CD70 (clone 1F6-C4v2)-bac-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1F6-C4v2 bac MMAF (Monomethyl auristatin F) Inquiry
ADC-W-362 Anti-CD70 (clone 1F6-C4v2)-bac-VC-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1F6-C4v2 bac-VC MMAF (Monomethyl auristatin F) Inquiry
ADC-W-363 Anti-CD70 (clone 1F6-C4v2)-Mc-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1F6-C4v2 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-364 Anti-CD70 (clone 1F6-C4v2)-Mc-VC-MMAF ADC Humanized Anti-CD70 lgG1 Antibody, clone # h1F6-C4v2 mc-VC (maleimidocaproyl-valine-citrulline) MMAF (Monomethyl auristatin F) Inquiry
Catalog Product name Antibody Dye Detection Method Excitation/Emission (nm) Data sheet Inquiry
ADC-FL-883 Vorsetuzumab-Alexa 350 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 350 Fluorescent 346/442 Inquiry
ADC-FL-884 Vorsetuzumab-Alexa 405 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 405 Fluorescent 401/421 Inquiry
ADC-FL-885 Vorsetuzumab-Alexa 488 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 488 Fluorescent 490/525 Inquiry
ADC-FL-886 Vorsetuzumab-Alexa 532 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 532 Fluorescent 532/554 Inquiry
ADC-FL-887 Vorsetuzumab-Alexa 546 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 546 Fluorescent 556/573 Inquiry
ADC-FL-888 Vorsetuzumab-Alexa 555 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 555 Fluorescent 555/580 Inquiry
ADC-FL-889 Vorsetuzumab-Alexa 568 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 568 Fluorescent 578/603 Inquiry
ADC-FL-890 Vorsetuzumab-Alexa 594 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 594 Fluorescent 590/617 Inquiry
ADC-FL-891 Vorsetuzumab-Alexa 647 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 647 Fluorescent 650/665 Inquiry
ADC-FL-892 Vorsetuzumab-Alexa 680 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 680 Fluorescent 679/702 Inquiry
ADC-FL-893 Vorsetuzumab-Alexa 750 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Alexa Fluor 750 Fluorescent 749/775 Inquiry
ADC-FL-894 Vorsetuzumab-Bodipy FL Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Bodipy FL Fluorescent 503/512 Inquiry
ADC-FL-895 Vorsetuzumab-Coumarin Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Coumarin Fluorescent 387/470 Inquiry
ADC-FL-896 Vorsetuzumab-Cy3 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Cy3 Fluorescent 554/568 Inquiry
ADC-FL-897 Vorsetuzumab-Cy5 Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Cy5 649/666 Inquiry
ADC-FL-898 Vorsetuzumab-Fluoresein Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Fluoresein 490/525 Inquiry
ADC-FL-899 Vorsetuzumab-OGreen Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Oregon green 501/526 Inquiry
ADC-FL-900 Vorsetuzumab-PBlue Humanized Anti-CD70 IgG1-kappa antibody, Vorsetuzumab Pafific blue 410/455 Inquiry
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