CD74

CD74, also known as IL, DHLAG, HLADG, Ia-GAMMA, or the invariant chain, is a B cell surface protein that is functionally important for the regulation of antigen presentation for immune responses. It is associated with class II major histocompatibility complex (MHC) and contains one thyroglobulin type-1 domain in its protein sequence. CD74 functions in the MHC class II antigen processing, where it stabilizes the peptide-free class II alpha/beta heterodimer complex and transports this complex from ER to the endosomal/lysosomal system for antigen processing and MHC binding. It is also a cell surface receptor for cytokine macrophage migration inhibitory factor (MIF) and promotes cell proliferation upon ligand interaction. CD74 has also been found to interact with amyloid precursor protein (APP), resulting in the suppression of amyloid beta (Abeta) production.

Abnormal CD74 interaction with MIF has been proven as a prognostic factor in several cancers and it is recently demonstrated as an important factor for malignant pleural mesothelioma (MPM). CD74 is associate with a variety of cancer types, including colorectal cancer, endometrial cancer, lymphoma…, making it an excellent target for cancer immunotherapies.

Entrez Gene ID: 972
UniProt ID: P04233

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-040 Anti-CD74 (006 (A))-Mc-MMAF ADC Anti-CD74 antibody, 006 (A) Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-041 Anti-CD74 (005 (A))-Mc-MMAF ADC Anti-CD74 antibody, 005 (A) Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-038 Anti-CD74 (005 (A))-VC-MMAE ADC Anti-CD74 antibody, 005 (A) VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-037 Anti-CD74 (006 (A))-VC-MMAE ADC Anti-CD74 antibody, 006 (A) VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-036 Anti-CD74 (011 (B))-VC-MMAE ADC Anti-CD74 antibody, 011 (B) VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-039 Anti-CD74 (011 (B))-Mc-MMAF ADC Anti-CD74 antibody, 011 (B) Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-378 Anti-CD74 (clone Hll1)-hindered disulfide-Doxorubicin ADC Humanized Anti-CD74 Antibody, clone # Hll1 hindered disulfide doxorubicin Inquiry
ADC-W-576 Anti-CD74 (clone hLL1)-CL2A-SN-38 ADC Humanized Anti-CD74 Antibody, clone # hLL1 CL2A SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-577 Anti-CD74 (clone hLL1)-CL2E-SN-38 ADC Humanized Anti-CD74 Antibody, clone # hLL1 CL2E SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-578 Anti-CD74 (clone hLL1)-MCC-Dox ADC Humanized Anti-CD74 Antibody, clone # hLL1 MCC (Maleimidomethyl cyclohexane-1-carboxylate) doxorubicin Inquiry
ADC-W-377 Anti-CD74 (clone HuMax)-Mc-VC-PABC-MMAF ADC Humanized Anti-CD74 Antibody, clone # HuMax MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-2548 Anti-CD74 (Milatuzumab)-SMCC-DM1 ADC Humanized Anti-CD74 IgG1-kappa antibody, Milatuzumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2549 Anti-CD74 (Milatuzumab)-SPDB-DM4 ADC Humanized Anti-CD74 IgG1-kappa antibody, Milatuzumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2550 Anti-CD74 (Milatuzumab)-MC-MMAF ADC Humanized Anti-CD74 IgG1-kappa antibody, Milatuzumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2551 Anti-CD74 (Milatuzumab)-MC-Vc-PAB-MMAE ADC Humanized Anti-CD74 IgG1-kappa antibody, Milatuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-2552 Anti-CD74 (Milatuzumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-CD74 IgG1-kappa antibody, Milatuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2553 Anti-CD74 (Milatuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-CD74 IgG1-kappa antibody, Milatuzumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-479  Anti-CD74 (clone hLL1)-SMCC-Dox ADC milatuzumab-dox(IMMU-110) Humanized Anti-ECD74 Antibody, clone # Hll1 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) Doxorubicin Inquiry
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