CD80

Cluster of differentiation 80 (CD80), also known as B7-1, is encoded by the CD80 gene. CD80 is a membrane receptor which is activated via the binding of CD28 (for autoregulation and intercellular association) or CTLA-4 (for attenuation of regulation and cellular disassociation).
Primarily, CD80 is expressed on dendritic cells, activated B cells and monocytes that offer a costimulatory signal essentially for T cell activation and survival. Generally, CD80 functions together with CD86 to prime T cells. A recent study has investigated the functions of B7 costimulatory molecules in vivo in B7-1 and/or B7-2 knockout mice, and they found that CD86 could be more important for initiating T-cell responses, however, CD80 could be more significant for maintaining these immune responses. In another research, scientists have compared the role of CD80 and CD86 in initiating and maintaining proliferation of resting CD4 (+) T cells in an in vitro mode system. Finally, they have proven that the CD80 and CD86 molecules enable to substitute for each other in the initial activation of resting CD4 (+) T cells, as well as in the maintenance of their proliferative response.
Gene ID: 941
UniProt ID: P33681