CEACAM1

Carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1), also known as BGP, BGP1, BGPI or Cluster of Differentiation 66a (CD66a), is a 160-kDa glycoprotein that is a member of the CEACAM branch of the CEA gene family. It also belongs to the immunoglobulin superfamily. Human CEACAM-1 protein is a 526-amino acid (aa) type I transmembrane protein that contains a 34-aa signal sequence, a 394-aa extracellular domain (ECD), a 24-aa transmembrane segment, and a 74-aa cytoplasmic region. In addition to the full-length form, this protein is reported to have 10 alternate spliced forms that include three soluble isoforms and seven transmembrane isoforms. The full-length molecule is expressed on neutrophils, bile duct epithelium, activated NK cells, colonic columnar epithelium and endothelium.

It has been implicated that the CEACAM1 protein is involved in various cellular activities, including angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. In other words, this protein plays an important role in governing the growth and differentiation of normal and cancerous cells as well as modulating multiple immune responses.

Gene ID: 634
UniProt ID: P13688