EPHB2

EPH receptor B2 (EPHB2), also goes by acronyms such as DRT, EK5, ERK, CAPB, Hek5, PCBC, EPHT3, or Tyro5, is a cell membrane Ephrin receptor. It contains two fibronectin type-III domains in the extracellular portion, one transmembrane domain, as well as one protein kinase domain (Tyr protein kinase family) and one SAM (sterile alpha motif) domain in the cytoplasmic region. EPHB2 is expressed in a variety of organs with a preference in fetal brain, and is involved in ephrin signaling and the downstream cellular processes that determine cell motility, division, and differentiation. One unique feature of the Eph-ephrin signaling involving EPHB2 is its bidirectional nature, where the signaling cascades can be trigger by both the receptors and ligands.

EPHB2 is involved in cAMP-Dependent PKA pathway and GPCR pathway. Defects in EPHB2 is speculated to increase the susceptibility for prostate cancer (PC). It is currently exploited as an appealing target for antibody-based immunotherapy development.

Entrez Gene ID: 2048
UniProt ID: P29323