ERBB3

Erb-b2 receptor tyrosine kinase 3 (ERBB3), also known as HER3, is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This protein contains a neuregulin binding domain but not an active kinase domain. However, it enables to bind this ligand but not convey the signal into the cell via protein phosphorylation, and produces heterodimers with other EGF receptor family members which do have kinase activity.
Generally, ERBB3 is co-expressed with other RTKs in cancer cells. It primarily enhances tumor initiation and progression by activation of the oncogenic PI-3 K/Akt signaling. Due to its role in therapeutic resistance, the ERBB3/PI-3 K/Akt pathway is the main cause of treatment failure in cancer therapy. Besides, ERBB3 serves an essential role in the development of a variety of human cancers, such as platinum-resistant/refractory ovarian cancer, erbB2-overexpressing (erbB2+) breast cancer, EGFR tyrosine kinase inhibitor (TKI)-resistant non-small cell lung cancer (NSCLC), as well as castration-resistant prostate cancer (CRPC). At present, a number of anti-ERBB3 monoclonal Abs that prevent ligand-induced activation of erbB3 have displayed significant antitumor activity in vitro and in vivo, for example, U3-1287/AMG 888 (Amgen Inc., Thousand Oaks, CA), MM-121 and MM-111 (Merrimack Pharmaceuticals, Cambridge, MA).
Gene ID: 2065
UniProt ID: P21860

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-2240 Anti-ERBB3 (Duligotumab)-SMCC-DM1 ADC Human Anti-ERBB3 IgG antibody, Duligotumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2241 Anti-ERBB3 (Duligotumab)-SPDB-DM4 ADC Human Anti-ERBB3 IgG antibody, Duligotumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2242 Anti-ERBB3 (Duligotumab)-MC-MMAF ADC Human Anti-ERBB3 IgG antibody, Duligotumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2243 Anti-ERBB3 (Duligotumab)-MC-Vc-PAB-MMAE ADC Human Anti-ERBB3 IgG antibody, Duligotumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-2244 Anti-ERBB3 (Duligotumab)-MC-Vc-PAB-SN38 ADC Human Anti-ERBB3 IgG antibody, Duligotumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2245 Anti-ERBB3 (Duligotumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-ERBB3 IgG antibody, Duligotumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1118 Anti-ERBB3 (Patritumab)-SMCC-DM1 ADC Human Anti-ERBB3 IgG1-kappa antibody, Patritumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1119 Anti-ERBB3 (Patritumab)-SPDB-DM4 ADC Human Anti-ERBB3 IgG1-kappa antibody, Patritumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1120 Anti-ERBB3 (Patritumab)-MC-MMAF ADC Human Anti-ERBB3 IgG1-kappa antibody, Patritumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1121 Anti-ERBB3 (Patritumab)-MC-Vc-PAB-MMAE ADC Human Anti-ERBB3 IgG1-kappa antibody, Patritumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1122 Anti-ERBB3 (Patritumab)-MC-Vc-PAB-SN38 ADC Human Anti-ERBB3 IgG1-kappa antibody, Patritumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1123 Anti-ERBB3 (Patritumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-ERBB3 IgG1-kappa antibody, Patritumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-2366 Anti-ERBB3 (Duligotuzumab)-SMCC-DM1 ADC Humanized Anti-ERBB3 IgG1-kappa antibody, Duligotuzumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2367 Anti-ERBB3 (Duligotuzumab)-SPDB-DM4 ADC Humanized Anti-ERBB3 IgG1-kappa antibody, Duligotuzumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2368 Anti-ERBB3 (Duligotuzumab)-MC-MMAF ADC Humanized Anti-ERBB3 IgG1-kappa antibody, Duligotuzumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2369 Anti-ERBB3 (Duligotuzumab)-MC-Vc-PAB-MMAE ADC Humanized Anti-ERBB3 IgG1-kappa antibody, Duligotuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-2370 Anti-ERBB3 (Duligotuzumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-ERBB3 IgG1-kappa antibody, Duligotuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2371 Anti-ERBB3 (Duligotuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-ERBB3 IgG1-kappa antibody, Duligotuzumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1124 Anti-ERBB3 (Seribantumab)-SMCC-DM1 ADC Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1125 Anti-ERBB3 (Seribantumab)-SPDB-DM4 ADC Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1126 Anti-ERBB3 (Seribantumab)-MC-MMAF ADC Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1127 Anti-ERBB3 (Seribantumab)-MC-Vc-PAB-MMAE ADC Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1128 Anti-ERBB3 (Seribantumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1129 Anti-ERBB3 (Seribantumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
Catalog Product name Antibody Dye Detection Method Excitation/Emission (nm) Data sheet Inquiry
ADC-FL-1387  Patritumab-Alexa 350 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 350 Fluorescent 346/442 Inquiry
ADC-FL-1388 Patritumab-Alexa 405 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 405 Fluorescent 401/421 Inquiry
ADC-FL-1389 Patritumab-Alexa 488 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 488 Fluorescent 490/525 Inquiry
ADC-FL-1390 Patritumab-Alexa 532 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 532 Fluorescent 532/554 Inquiry
ADC-FL-1391 Patritumab-Alexa 546 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 546 Fluorescent 556/573 Inquiry
ADC-FL-1392 Patritumab-Alexa 555 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 555 Fluorescent 555/580 Inquiry
ADC-FL-1393 Patritumab-Alexa 568 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 568 Fluorescent 578/603 Inquiry
ADC-FL-1394 Patritumab-Alexa 594 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 594 Fluorescent 590/617 Inquiry
ADC-FL-1395 Patritumab-Alexa 647 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 647 Fluorescent 650/665 Inquiry
ADC-FL-1396 Patritumab-Alexa 680 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 680 Fluorescent 679/702 Inquiry
ADC-FL-1397 Patritumab-Alexa 750 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Alexa Fluor 750 Fluorescent 749/775 Inquiry
ADC-FL-1398 Patritumab-Bodipy FL Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Bodipy FL Fluorescent 503/512 Inquiry
ADC-FL-1399 Patritumab-Coumarin Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Coumarin Fluorescent 387/470 Inquiry
ADC-FL-1400 Patritumab-Cy3 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Cy3 Fluorescent 554/568 Inquiry
ADC-FL-1401 Patritumab-Cy5 Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Cy5 649/666 Inquiry
ADC-FL-1402 Patritumab-Fluoresein Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Fluoresein 490/525 Inquiry
ADC-FL-1403 Patritumab-OGreen Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Oregon green 501/526 Inquiry
ADC-FL-1404 Patritumab-PBlue Human Anti-ERBB3 IgG1-kappa antibody, Patritumab Pafific blue 410/455 Inquiry
ADC-FL-1405 Seribantumab-Alexa 350 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 350 Fluorescent 346/442 Inquiry
ADC-FL-1406 Seribantumab-Alexa 405 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 405 Fluorescent 401/421 Inquiry
ADC-FL-1407 Seribantumab-Alexa 488 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 488 Fluorescent 490/525 Inquiry
ADC-FL-1408 Seribantumab-Alexa 532 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 532 Fluorescent 532/554 Inquiry
ADC-FL-1409 Seribantumab-Alexa 546 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 546 Fluorescent 556/573 Inquiry
ADC-FL-1410 Seribantumab-Alexa 555 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 555 Fluorescent 555/580 Inquiry
ADC-FL-1411 Seribantumab-Alexa 568 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 568 Fluorescent 578/603 Inquiry
ADC-FL-1412 Seribantumab-Alexa 594 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 594 Fluorescent 590/617 Inquiry
ADC-FL-1413 Seribantumab-Alexa 647 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 647 Fluorescent 650/665 Inquiry
ADC-FL-1414 Seribantumab-Alexa 680 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 680 Fluorescent 679/702 Inquiry
ADC-FL-1415 Seribantumab-Alexa 750 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Alexa Fluor 750 Fluorescent 749/775 Inquiry
ADC-FL-1416 Seribantumab-Bodipy FL Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Bodipy FL Fluorescent 503/512 Inquiry
ADC-FL-1417 Seribantumab-Coumarin Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Coumarin Fluorescent 387/470 Inquiry
ADC-FL-1418 Seribantumab-Cy3 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Cy3 Fluorescent 554/568 Inquiry
ADC-FL-1419 Seribantumab-Cy5 Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Cy5 649/666 Inquiry
ADC-FL-1420 Seribantumab-Fluoresein Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Fluoresein 490/525 Inquiry
ADC-FL-1421 Seribantumab-OGreen Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Oregon green 501/526 Inquiry
ADC-FL-1422 Seribantumab-PBlue Humanized Anti-ERBB3 IgG2-lambda antibody, Seribantumab Pafific blue 410/455 Inquiry
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