F3

Coagulation factor III (F3), also known as tissue factor, TF, TFA or CD142, is a cell surface glycoprotein that belongs to the cytokine receptor protein superfamily. This factor contains 3 distinct domains, an extracellular domain consisting of two fibronectin type III modules and serving as a template for factor VIIa binding, a transmembrane domain and a cytosolic domain that is involved in the signaling function of TF. The expression of this tissue receptor is found in cells that are normally not exposed to flowing blood such as sub-endothelial cells and cells surrounding blood vessels.
The best known function of this factor is enabling cells to initiate the blood coagulation cascades. As the high-affinity receptor for the coagulation factor VII, this receptor can form a complex with blood-coagulation factor VIIa, providing a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis.

Gene ID: 2152
UniProt ID: P13726