FOLH1

Folate hydrolase 1 (FOLH1), also known as PSMA, is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Typically, FOLH1 function as a glutamate carboxypeptidase. In the intestines, the enzyme is termed folate hydrolase, and is expressed on brush border membranes where it is associated with the sequential cleavage of terminal γ-linked glutamate residues from dietary polyglutamyl folates to allow the absorption of folate. Apart from the gut, the enzyme is also highly expressed in the neovasculature of solid tumors and prostate cancer, in which it is called prostate-specific membrane antigen (PSMA) and acts as a cancer biomarker.
In addition, in the brain and peripheral nervous system, the enzyme is referred to as glutamate carboxypeptidase II (GCPII), which cleaves the abundant dipeptide neurotransmitter N-acetylaspartylglutamate (NAAG) to liberate glutamate. Importantly, many classes of strong and selective small-molecule GCPII inhibitors have been synthesized and proven to have profound therapeutic effects in various preclinical models of neurological disorders wherein excess glutamate is implicated. It has also demonstrated that a mutation of the FOLH1 gene may be related to impaired intestinal absorption of dietary folates, leading to low blood folate levels and consequent hyperhomocysteinemia.
Gene ID: 2346
UniProt ID: Q04609

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-603  Anti-FOLH1 (clone J591)-SMCC-DM1 ADC MLN2704 Anti-FOLH1 Antibody, clone # J591 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1160 Anti-FOLH1 (Capromab)-SMCC-DM1 ADC Humanized Anti-FOLH1 IgG1-kappa antibody, Capromab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1161 Anti-FOLH1 (Capromab)-SPDB-DM4 ADC Humanized Anti-FOLH1 IgG1-kappa antibody, Capromab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1162 Anti-FOLH1 (Capromab)-MC-MMAF ADC Humanized Anti-FOLH1 IgG1-kappa antibody, Capromab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1163 Anti-FOLH1 (Capromab)-MC-Vc-PAB-MMAE ADC Humanized Anti-FOLH1 IgG1-kappa antibody, Capromab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1164 Anti-FOLH1 (Capromab)-MC-Vc-PAB-SN38 ADC Humanized Anti-FOLH1 IgG1-kappa antibody, Capromab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1165 Anti-FOLH1 (Capromab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-FOLH1 IgG1-kappa antibody, Capromab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-118 Anti-FOLH1 (clone 2A10)-cytotoxin Compound A ADC Anti-FOLH1-antibody, clone # 2A10 cytotoxin Compound A Inquiry
ADC-W-156 Anti-FOLH1-Mc-VC-PABC-MMAE ADC Anti-FOLH1 antibody MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-157 Anti-FOLH1-VC-MMAF ADC Anti-FOLH1 antibody VC (valine-citrulline) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-158 Anti-FOLH1-Mc-MMAF ADC Anti-FOLH1 antibody Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-431 Anti-FOLH1 (MLN591)-VC-MMAE ADC Anti-FOLH1 lgG1 Antibody, MLN591 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-432 Anti-FOLH1 (MLN591)-Mc-VC-MMAE ADC Anti-FOLH1 lgG1 Antibody, MLN591 mc-VC (maleimidocaproyl-valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-433 Anti-FOLH1 (MLN591)-thioester-DM1 ADC Anti-FOLH1 lgG1 Antibody, MLN591 thioester DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-470 Anti-FOLH1-VC-MMAE ADC Human Anti-FOLH1 lgG1 Antibody VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
Catalog Product name Antibody Dye Detection Method Excitation/Emission (nm) Data sheet Inquiry
ADC-FL-1513  Capromab-Alexa 350 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 350 Fluorescent 346/442 Inquiry
ADC-FL-1514 Capromab-Alexa 405 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 405 Fluorescent 401/421 Inquiry
ADC-FL-1515 Capromab-Alexa 488 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 488 Fluorescent 490/525 Inquiry
ADC-FL-1516 Capromab-Alexa 532 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 532 Fluorescent 532/554 Inquiry
ADC-FL-1517 Capromab-Alexa 546 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 546 Fluorescent 556/573 Inquiry
ADC-FL-1518 Capromab-Alexa 555 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 555 Fluorescent 555/580 Inquiry
ADC-FL-1519 Capromab-Alexa 568 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 568 Fluorescent 578/603 Inquiry
ADC-FL-1520 Capromab-Alexa 594 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 594 Fluorescent 590/617 Inquiry
ADC-FL-1521 Capromab-Alexa 647 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 647 Fluorescent 650/665 Inquiry
ADC-FL-1522 Capromab-Alexa 680 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 680 Fluorescent 679/702 Inquiry
ADC-FL-1523 Capromab-Alexa 750 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Alexa Fluor 750 Fluorescent 749/775 Inquiry
ADC-FL-1524 Capromab-Bodipy FL Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Bodipy FL Fluorescent 503/512 Inquiry
ADC-FL-1525 Capromab-Coumarin Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Coumarin Fluorescent 387/470 Inquiry
ADC-FL-1526 Capromab-Cy3 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Cy3 Fluorescent 554/568 Inquiry
ADC-FL-1527 Capromab-Cy5 Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Cy5 649/666 Inquiry
ADC-FL-1528 Capromab-Fluoresein Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Fluoresein 490/525 Inquiry
ADC-FL-1529 Capromab-OGreen Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Oregon green 501/526 Inquiry
ADC-FL-1530 Capromab-PBlue Murine Anti-FOLH1 IgG1-kappa antibody, Capromab Pafific blue 410/455 Inquiry

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