FUT4

Fucosyltransferase 4 (FUT4), also known as myeloid-type α1 or 3FUT, is an enzyme which in humans is encoded by the FUT4 gene. This enzyme transfers fucose to N-acetyllactosamine polysaccharides to form fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x. FUT4 is widely expressed in a number of tissues and not only in leukocytes. And in former studies, researchers could not find any human tissues in which FUT4 is absent. However, a variety of the tissues do not necessarily express the CD15 antigen.
In general, overexpression of the FUT4 gene by its transfection leads to the expression of CD15 on the cell surface, however, FUT7 transfection causes the expression of CD15s but not CD15. Thus, FUT4 was considered to be the enzyme solely responsible for the expression of CD15 in leukocytes before the finding of FUT9 in those cells. The CD15 epitope is expressed in several tissues, including certain neurons, epithelial cells of intestinal tissues, as well as glial cells in the central nervous system. Furthermore, in human leukocytes, CD15 is expressed preferentially in mature neutrophils, monocytes, and all myeloid cells from the promyelocyte stage onwards, allowing it a powerful cell surface marker.
Gene ID: 2526
UniProt ID: P22083

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-2456 Anti-FUT4 (Fanolesomab)-SMCC-DM1 ADC Anti-FUT4 IgG antibody, Fanolesomab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2457 Anti-FUT4 (Fanolesomab)-SPDB-DM4 ADC Anti-FUT4 IgG antibody, Fanolesomab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2458 Anti-FUT4 (Fanolesomab)-MC-MMAF ADC Anti-FUT4 IgG antibody, Fanolesomab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2459 Anti-FUT4 (Fanolesomab)-MC-Vc-PAB-MMAE ADC Anti-FUT4 IgG antibody, Fanolesomab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-2460 Anti-FUT4 (Fanolesomab)-MC-Vc-PAB-SN38 ADC Anti-FUT4 IgG antibody, Fanolesomab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2461 Anti-FUT4 (Fanolesomab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Anti-FUT4 IgG antibody, Fanolesomab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1172 Anti-FUT4 (Technetium (99mTc) fanolesomab)-SMCC-DM1 ADC Humanized Anti-FUT4 IgM antibody, Technetium (99mTc) fanolesomab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1173 Anti-FUT4 (Technetium (99mTc) fanolesomab)-SPDB-DM4 ADC Humanized Anti-FUT4 IgM antibody, Technetium (99mTc) fanolesomab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1174 Anti-FUT4 (Technetium (99mTc) fanolesomab)-MC-MMAF ADC Humanized Anti-FUT4 IgM antibody, Technetium (99mTc) fanolesomab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1175 Anti-FUT4 (Technetium (99mTc) fanolesomab)-MC-Vc-PAB-MMAE ADC Humanized Anti-FUT4 IgM antibody, Technetium (99mTc) fanolesomab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1176 Anti-FUT4 (Technetium (99mTc) fanolesomab)-MC-Vc-PAB-SN38 ADC Humanized Anti-FUT4 IgM antibody, Technetium (99mTc) fanolesomab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1177 Anti-FUT4 (Technetium (99mTc) fanolesomab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-FUT4 IgM antibody, Technetium (99mTc) fanolesomab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
Catalog Product name Antibody Dye Detection Method Excitation/Emission (nm) Data sheet Inquiry
ADC-FL-1549  Fanolesomab-Alexa 350 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 350 Fluorescent 346/442 Inquiry
ADC-FL-1550 Fanolesomab-Alexa 405 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 405 Fluorescent 401/421 Inquiry
ADC-FL-1551 Fanolesomab-Alexa 488 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 488 Fluorescent 490/525 Inquiry
ADC-FL-1552 Fanolesomab-Alexa 532 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 532 Fluorescent 532/554 Inquiry
ADC-FL-1553 Fanolesomab-Alexa 546 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 546 Fluorescent 556/573 Inquiry
ADC-FL-1554 Fanolesomab-Alexa 555 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 555 Fluorescent 555/580 Inquiry
ADC-FL-1555 Fanolesomab-Alexa 568 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 568 Fluorescent 578/603 Inquiry
ADC-FL-1556 Fanolesomab-Alexa 594 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 594 Fluorescent 590/617 Inquiry
ADC-FL-1557 Fanolesomab-Alexa 647 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 647 Fluorescent 650/665 Inquiry
ADC-FL-1558 Fanolesomab-Alexa 680 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 680 Fluorescent 679/702 Inquiry
ADC-FL-1559 Fanolesomab-Alexa 750 Anti-FUT4 IgM antibody, Fanolesomab Alexa Fluor 750 Fluorescent 749/775 Inquiry
ADC-FL-1560 Fanolesomab-Bodipy FL Anti-FUT4 IgM antibody, Fanolesomab Bodipy FL Fluorescent 503/512 Inquiry
ADC-FL-1561 Fanolesomab-Coumarin Anti-FUT4 IgM antibody, Fanolesomab Coumarin Fluorescent 387/470 Inquiry
ADC-FL-1562 Fanolesomab-Cy3 Anti-FUT4 IgM antibody, Fanolesomab Cy3 Fluorescent 554/568 Inquiry
ADC-FL-1563 Fanolesomab-Cy5 Anti-FUT4 IgM antibody, Fanolesomab Cy5 649/666 Inquiry
ADC-FL-1564 Fanolesomab-Fluoresein Anti-FUT4 IgM antibody, Fanolesomab Fluoresein 490/525 Inquiry
ADC-FL-1565 Fanolesomab-OGreen Anti-FUT4 IgM antibody, Fanolesomab Oregon green 501/526 Inquiry
ADC-FL-1566 Fanolesomab-PBlue Anti-FUT4 IgM antibody, Fanolesomab Pafific blue 410/455 Inquiry
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