GD2

CD2 was discovered in 1942. It is a disialoganglioside expressed on tumors of neuroectodermal origin. Gangliosides are composed of glycosphingolipid and sialic acids (N-acetylneuraminic acid, Neu5Ac or NANA), which are nine-carbon monosaccharides. GD2 has two NANA (α-2,8 bound sialic acid and α-2,3 bound sialic acid), and is derived from precursor GD3 by adding Gal-NAc through the enzyme GM2/GD2 synthase (β1,4-N-acetylgalactosaminyltransferase). GD2 is expressed on neural stem cells, mesenchymal stem cells (MSCs) and peripheral sympathoadrenergic progenitors, and it is involved in neural differentiation and proliferation.

After birth, the GD2 expression is restricted to the CNS, predominantly in neuronal cell bodies, and MSCs, as well as peripheral nerves and skin melanocytes at low levels. GD2 is thought to play a role in the maintenance and repair of nervous tissues, which undergo continually progressive degenerative changes through the regulation of complement activation and subsequent inflammation, although the exact immunologic mechanism remains obscure. GD2(+) MSCs have the potentials to differentiate into multiple lineages, including neurons. GD2 is highly expressed on a variety of embryonal cancers, bone tumors, soft tissue sarcomas, neural crest-derived tumors and breast cancer.

If you can’t find your product on this list? Please directly send email to

For Research Use Only. NOT FOR CLINICAL USE.


Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:









Customized FluoroAb™

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA
 
 Tel:
 Fax:
 Email:
Europe
 
 Tel:
 Email:
Germany
 
 Tel:
 Email:


Inquiry

Top