ICAM1

Intercellular adhesion molecule 1 (ICAM1) is a cell surface glycoprotein, also called CD54 or BB2. It is one of the members of intercellular adhesion molecules (ICAMs) and is usually expressed on endothelial cells and cells of the immune system. ICAMs are cell surface glycoproteins expressed on various cell types, with distinct patterns of gene modulation and effector functions. On account of its extensive distribution and specific regulation, ICAM-1 is the most broadly studied of the five ICAM molecules.
ICAM1 contains five Ig-like domains, of which the first domain functions by binding to LFA-1, while the third domain responsible for binding to MAC-1. Importantly, stimulation of many cells with inflammatory cytokines, for example, tumor necrosis factor (TNF) α, nterleukin (IL)-1, lipopolysaccharide (LPS), and interferon (IFN) γhas been shown to improve ICAM1 expression on various cell types. Besides, ICAMs may serve an important role in the development of the nervous system, in immune and inflammatory responses, and in embryonic development. Moreover, ICAM1 acts an essential role in trafficking of inflammatory cells, in leukocyte effector functions, in microbial pathogenesis, in adhesion of antigen-presenting cells to T lymphocytes during antigen presentation, and in signal transduction pathways through outside-in signaling events.
Gene ID: 3383
UniProt ID: P05362