IGF1R

Insulin-like growth factor 1 receptor (IGF1R), also called CD221 or JTK13, is a protein identified on the surface of human cells, belonging to the large class of tyrosine kinase receptors. This protein is a transmembrane receptor activated via the insulin-like growth factor 1 (IGF-1) and a related hormone called IGF-2. It mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin.
IGF1R composed of two α subunits and two β subunits, both of which are synthesized from a single mRNA precursor. The α chains are located extracellularly, however, the β subunit spans the membrane and play an important role in intracellular signal transduction upon ligand stimulation. The molecular weight of mature IGF1R is about 320 kDa. Importantly, IGF1R is associated with a number of cancers, such as prostate, breast and lung cancers. In some situations, its anti-apoptotic features enable cancerous cells to resist the cytotoxic properties of chemotherapeutic drugs or radiotherapy. In addition, it has proven that improved levels of the IGF-IR are expressed in the most primary and metastatic prostate cancer patient tumors.
Gene ID: 3480
UniProt ID: P08069