IGF1R

Insulin-like growth factor 1 receptor (IGF1R), also called CD221 or JTK13, is a protein identified on the surface of human cells, belonging to the large class of tyrosine kinase receptors. This protein is a transmembrane receptor activated via the insulin-like growth factor 1 (IGF-1) and a related hormone called IGF-2. It mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin.
IGF1R composed of two α subunits and two β subunits, both of which are synthesized from a single mRNA precursor. The α chains are located extracellularly, however, the β subunit spans the membrane and play an important role in intracellular signal transduction upon ligand stimulation. The molecular weight of mature IGF1R is about 320 kDa. Importantly, IGF1R is associated with a number of cancers, such as prostate, breast and lung cancers. In some situations, its anti-apoptotic features enable cancerous cells to resist the cytotoxic properties of chemotherapeutic drugs or radiotherapy. In addition, it has proven that improved levels of the IGF-IR are expressed in the most primary and metastatic prostate cancer patient tumors.
Gene ID: 3480
UniProt ID: P08069

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-1250 Anti-IGF1R (Robatumumab)-SMCC-DM1 ADC Human Anti-IGF1R IgG1-kappa antibody, Robatumumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1251 Anti-IGF1R (Robatumumab)-SPDB-DM4 ADC Human Anti-IGF1R IgG1-kappa antibody, Robatumumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1252 Anti-IGF1R (Robatumumab)-MC-MMAF ADC Human Anti-IGF1R IgG1-kappa antibody, Robatumumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1253 Anti-IGF1R (Robatumumab)-MC-Vc-PAB-MMAE ADC Human Anti-IGF1R IgG1-kappa antibody, Robatumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1254 Anti-IGF1R (Robatumumab)-MC-Vc-PAB-SN38 ADC Human Anti-IGF1R IgG1-kappa antibody, Robatumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1255 Anti-IGF1R (Robatumumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-IGF1R IgG1-kappa antibody, Robatumumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1244 Anti-IGF1R (Cixutumumab)-SMCC-DM1 ADC Human Anti-IGF1R IgG1-lambda antibody, Cixutumumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1245 Anti-IGF1R (Cixutumumab)-SPDB-DM4 ADC Human Anti-IGF1R IgG1-lambda antibody, Cixutumumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1246 Anti-IGF1R (Cixutumumab)-MC-MMAF ADC Human Anti-IGF1R IgG1-lambda antibody, Cixutumumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1247 Anti-IGF1R (Cixutumumab)-MC-Vc-PAB-MMAE ADC Human Anti-IGF1R IgG1-lambda antibody, Cixutumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1248 Anti-IGF1R (Cixutumumab)-MC-Vc-PAB-SN38 ADC Human Anti-IGF1R IgG1-lambda antibody, Cixutumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1249 Anti-IGF1R (Cixutumumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-IGF1R IgG1-lambda antibody, Cixutumumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1256 Anti-IGF1R (Figitumumab)-SMCC-DM1 ADC Human Anti-IGF1R IgG2-kappa antibody, Figitumumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1257 Anti-IGF1R (Figitumumab)-SPDB-DM4 ADC Human Anti-IGF1R IgG2-kappa antibody, Figitumumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1258 Anti-IGF1R (Figitumumab)-MC-MMAF ADC Human Anti-IGF1R IgG2-kappa antibody, Figitumumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1259 Anti-IGF1R (Figitumumab)-MC-Vc-PAB-MMAE ADC Human Anti-IGF1R IgG2-kappa antibody, Figitumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1260 Anti-IGF1R (Figitumumab)-MC-Vc-PAB-SN38 ADC Human Anti-IGF1R IgG2-kappa antibody, Figitumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1261 Anti-IGF1R (Figitumumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-IGF1R IgG2-kappa antibody, Figitumumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1262 Anti-IGF1R (Dalotuzumab)-SMCC-DM1 ADC Humanized Anti-IGF1R Anti-IGF1R IgG1-kappa antibody, Dalotuzumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1263 Anti-IGF1R (Dalotuzumab)-SPDB-DM4 ADC Humanized Anti-IGF1R Anti-IGF1R IgG1-kappa antibody, Dalotuzumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1264 Anti-IGF1R (Dalotuzumab)-MC-MMAF ADC Humanized Anti-IGF1R Anti-IGF1R IgG1-kappa antibody, Dalotuzumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1265 Anti-IGF1R (Dalotuzumab)-MC-Vc-PAB-MMAE ADC Humanized Anti-IGF1R Anti-IGF1R IgG1-kappa antibody, Dalotuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1266 Anti-IGF1R (Dalotuzumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-IGF1R Anti-IGF1R IgG1-kappa antibody, Dalotuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1267 Anti-IGF1R (Dalotuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-IGF1R Anti-IGF1R IgG1-kappa antibody, Dalotuzumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
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