IL22

IL22, also known as TIFa, is a cytokine which is essential for the regulation of tissue responses during inflammation. IL-22 binds to a heterodimeric cell surface receptor made up of IL-10R2 and IL-22R1 subunits. By activation of Stat3-signaling cascades, IL22 enables to induce proliferative, anti-apoptotic pathways, and anti-microbial molecules, which assist to prevent tissue damage and help in its repair. This cytokine is produced via both the adaptive arm of the immune system, including CD4 T-cell subsets, as well as by innate lymphocytes, such as NK cells and LTi-like cells. It serves an essential role in inflammation, such as chronic inflammatory diseases and infectious diseases.
Besides, binding of IL22 to its receptor results in activation of Stat3 signaling cascades, as well as Akt and mitogen-activated protein kinase pathways. It also induces proliferative and anti-apoptotic pathways in responsive cells responsible for tissue preservation. IL-22 is expressed on a great number of lymphocytes, comprising both those of the innate and adaptive immune system, which contains CD4 T cells, γδ T cells, LTi cells, NK cells, as well as most notably Th17 cells.
Gene ID: 50616
UniProt ID: Q9GZX6

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